健康育龄男性精液常规参数增龄性变化分析  

Analysis of aging changes of semen routine parameters in healthy men of childbearing age

作　　者：王晓琳 李蕾[1] 张雁冰[1] 孙健武[1] 王培昌[1] Wang Xiaolin;Li Lei;Zhang Yanbing;Sun Jianwu;Wang Peichang(Department of Laboratory,Xuanwu Hospital,Capital Medical University Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院检验科,北京100032

出　　处：《北京医学》2023年第7期599-602,共4页Beijing Medical Journal

基　　金：国家自然科学基金(81871714);北京市医院管理局临床医学发展专项——“扬帆”计划(ZYLX202114)。

摘　　要：目的探讨男性精液质量与年龄的关系。方法选取2022年首都医科大学宣武医院泌尿外科行生育健康咨询(备孕人群)和婚前检查、体检的男性1150例,按年龄分为<26岁组(n=56)、26~<31岁组(n=336)、31~<36岁组(n=438)、36~<41岁组(n=210)及≥41岁组(n=110),比较不同年龄组精液常规检测参数。结果1150例男性年龄18~66岁,平均(33.1±5.8)岁,其中行生育健康咨询(备孕人群)646例、婚前检查及体检504例。1150例男性中精液质量异常结果584例(50.78%),其中精子向前运动异常率与精子总活力异常率高于精液检测的其他项目,差异有统计学意义(P<0.05)。5组液化时间、pH值及精子浓度的比较,差异均无统计学意义(P>0.05);26~<31岁组精液量、精子总数最高,≥41岁组最低,各组比较的差异有统计学意义(P<0.05);精子向前运动百分率与精子总活力随年龄增大呈先升高后降低的趋势,其中≥41岁组最低(P<0.05)。结论男性精液异常主要表现为精子总活力及向前运动异常,且41岁后精液量、精子总数及精子活力下降明显。Objective To explore the relationship between male semen quality and age.Methods A total of 1150 male who underwent reproductive health counseling(pregnancy population),premarital examination and physical examination in the Department of Urology of Xuanwu Hospital,Capital Medical University in 2022 were selected,and were divided into<26 years old group(n=56),26~<31 years old group(n=336),31~<36 years old group(n=438),36~<41 years old group(n=210),and≥41 years old group(n=110)according to age,and the parameters of routine semen detection in different age groups were compared.Results The 1150 males aged from 18 to 66 years,with an average age of(33.1±5.8)years,of which 646 cases were for reproductive health consultation(pregnant population),and 504 cases were for premarital examination and physical examination.Among the 1150 cases,584 cases(50.78%)reported abnormal semen quality results.The percentage of abnormal sperm forward movement and the proportion of abnormal sperm total motility results were significantly higher than other semen detection items,and the difference were statistically significant(P<0.05).There was no significant difference in liquefaction time,pH value and sperm concentration among the five groups(P>0.05).The semen volume and total sperm count were highest in the 26~<31 years old group,and the lowest in the≥41 years old group,the difference were statistically significant(P<0.05).The percentage of sperm forward movement and total sperm motility showed a trend of first increasing and then decreasing with age,with the lowest in the≥41 years old group(P<0.05).Conclusions The abnormal semen of men mainly manifested in the abnormal total sperm motility and forward movement,while the semen volume,total sperm and sperm motility decrease significantly after 41 years old.

关 键 词：健康育龄 精液 增龄性 男性 

分 类 号：R698.2[医药卫生—泌尿科学]