苯唑西林敏感耐甲氧西林金黄色葡萄球菌耐药机制研究进展  

Research Progress on Drug Resistance Mechanism of Oxacillin Sensitive Methicillin-Resistant Staphylococcus Aureus (OS-MRSA)

作　　者：田媛 孙刚 TIAN Yuan;SUN Gang(Inner Mongolia Minzu University,Tongliao,Inner Mongolia 028000;Laboratory Department,Inner Mongolia Forestry General Hospital,Yakeshi,Inner Mongolia 022150)

机构地区：[1]内蒙古民族大学,内蒙古通辽028000 [2]内蒙古林业总医院检验科,内蒙古牙克石022150

出　　处：《智慧健康》2023年第17期50-53,共4页Smart Healthcare

基　　金：内蒙古自治区卫生健康委医疗卫生科技计划项目《呼伦贝尔地区OS-MRSA的分子流行病学特征及生物膜形成能力研究》(项目编号:202201607)。

摘　　要：苯唑西林敏感耐甲氧西林金黄色葡萄球菌(OS-MRSA)为耐甲氧西林金黄色葡萄球菌(MRSA)的一种特殊耐药基因型,其特点为携带mecA基因,但对苯唑西林敏感,由于其对苯唑西林常显示为最小抑制浓度(通常最小抑制浓度≤2μg/mL),因此这些分离株经常被表型方法错误地鉴定为甲氧西林敏感金黄色葡萄球菌(MSSA),错误的鉴定结果常误导临床治疗,引起感染迁延不愈,甚至治疗失败。本文从流行病学、耐药机制及实验室检查等方面对OS-MRSA进行综述。Oxacillin sensitive Methicillin-resistant Staphylococcus aureus(OS-MRSA)is a special drug resistant genotype of Methicillin-resistant Staphylococcus aureus(MRSA),which is characterized by carrying mecA gene,but sensitive to Oxacillin.Because of its low MIC(usually≤2μg/ml),these isolates are often incorrectly identified as Methicillin sensitive Staphylococcus aureus(MSSA)by phenotypic methods and wrong identification results often mislead clinical treatment,cause infection to persist or even treatment failure.The article reviews Oxacillin sensitive and Methicillin resistant golden grape balls(OS-MRSA)from aspects of epidemiology,drug resistance mechanism and laboratory tests.

关 键 词：苯唑西林敏感耐甲氧西林金黄色葡萄球菌(OS-MRSA) 耐药机制 实验室检查 

分 类 号：R446.5[医药卫生—诊断学]