左乙拉西坦不良反应分析  

Adverse reactions caused by levetiracetam

作　　者：梁栋 罗莉 程均祥 LIANG Dong;LUO Li;CHENG Junxiang(Department of Pharmacy,the First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei Anhui 230036,China;The People’s Hospital of Feidong,Feidong Anhui 231600,China)

机构地区：[1]中国科学技术大学附属第一医院,安徽省立医院药学部,安徽合肥230036 [2]安徽省肥东县人民医院,安徽肥东231600

出　　处：《中国药物警戒》2023年第9期1054-1059,共6页Chinese Journal of Pharmacovigilance

基　　金：安徽省卫生健康委科研项目(AHWJ2021b017)。

摘　　要：目的 分析左乙拉西坦致药品不良反应(ADR)情况和临床特点,为临床安全用药提供参考。方法 检索中国知网、维普网、万方数据、中国生物医学文献数据库、PubMed、Embase、Web of Science等数据库,检索时限为1999年1月1日至2022年11月1日,对左乙拉西坦致ADR的个案报道进行分析。结果 共获得文献77篇,纳入患者85例,其中男性37例,女性48例。使用左乙拉西坦后出现ADR最短时间为用药后5 min,最长为4年,63.53%发生在用药后30 d内。左乙拉西坦致ADR主要涉及精神异常(28.42%)、皮肤及其附件损害(17.89%)、血液和淋巴系统异常(13.68%)。在85例患者中,55例患者仅作停药处理后痊愈或好转。结论 左乙拉西坦可引发一些新的及严重的ADR,需提高医务工作者对其所致ADR的认知,加强其用药过程监测,保障患者用药安全。Objective To analyze the occurrence and clinical characteristics of adverse drug reactions(ADR)induced by levetiracetam and to promote rational clinical drug use.Methods Case reports about ADR induced by levetiracetam in Chinese and English databases between January 1,1999 and November 1,2022 were collected and analyzed.Results A total of 77 articles about ADR caused by levetiracetam were retrieved and 85 patients(37 men and 48 women)were included.ADR mainly occurred within 30 days(63.53%)of therapy.The top three adverse drug reactions were respectively mental disorders(28.42%),skin and its appendage damage(17.89%)and blood and lymphatic system abnormalities(13.68%).Conclusion Levetiracetam can cause some new and serious ADR.It is necessary to raise the awareness of ADR caused by levetiracetam while medication should be monitored more rigorously to ensure the safety and efficacy of drug use.

关 键 词：左乙拉西坦 精神异常 皮肤及其附件损害 血液和淋巴系统异常 药品不良反应 

分 类 号：R971.6[医药卫生—药品] R994[医药卫生—药学]