盐酸拉贝洛尔片致妊娠期高血压伴银屑病患者皮疹加重1例分析  

Psoriasis aggravated by labetalol during pregnancy:a case report

作　　者：张晴 朱磊[2] 蔺存莲[2] 解沛涛 杨俊丽[1] 苏长海[1] ZHANG Qing;ZHU Lei;LIN Cunlian;XIE Peitao;YANG Junli;SU Changhai(Pharmacy Department of Ordos Central Hospital,Ordos Inner Mongolia 017000,China;Obstetrics and Gynecology Department of Ordos Central Hospital,Ordos Inner Mongolia 017000,China)

机构地区：[1]鄂尔多斯市中心医院药剂科,内蒙古鄂尔多斯017000 [2]鄂尔多斯市中心医院妇产科,内蒙古鄂尔多斯017000

出　　处：《中国药物警戒》2023年第9期1060-1063,共4页Chinese Journal of Pharmacovigilance

基　　金：鄂尔多斯市卫生健康委员会医学重点学科建设项目(鄂卫健发[2020]230号)。

摘　　要：目的 探讨盐酸拉贝洛尔片治疗妊娠期高血压加重银屑病病例,为临床安全用药提供参考。方法 分析1例盐酸拉贝洛尔片加重妊娠期高血压伴银屑病的治疗过程,结合文献资料,探讨盐酸拉贝洛尔片引起皮疹的作用机制及特点。结果 盐酸拉贝洛尔片加重妊娠期高血压伴银屑病病情,使患者皮疹症状加重。结论 特殊人群银屑病的治疗过程中需敏锐识别药品不良反应,β受体阻滞剂对于伴银屑病的妊娠期高血压患者要谨慎使用。Objective To study the applicability of labetalol hydrochloride tablets in the treatment of gestational hypertension with psoriasis so as to provide reference for safe clinical use of the drug.Methods One case of gestational hypertension with psoriasis aggravated by labetalol hydrochloride tablets in our hospital was analyzed.The mechanism of action and characteristics of skin rash caused by labetalol hydrochloride tablets were explored by referring to literature.Results Labetalol hydrochloride tablets aggravated psoriasis in this patient with hypertension during pregnancy.Conclusion Clinical pharmacists should be sensitive to the adverse drug reactions in the treatment of psoriasis in special populations.Beta-blockers should be used with caution in patients with hypertension complicated with psoriasis during pregnancy.

关 键 词：盐酸拉贝洛尔片 妊娠 高血压 银屑病 药品不良反应 

分 类 号：R984[医药卫生—药品] R972.4[医药卫生—药学] R994