补肾调冲方治疗薄型子宫内膜不孕症患者的临床观察  

Clinical Efficacy of Bushen Tiaochong Prescription for Improving Thin Endometrium-induced Infertility

作　　者：孟丹 许琳[2] 赵红[2] MENG Dan;XU Lin;ZHAO Hong(Shenmu Hospital of Northwest University,Shenmu Shaanxi 719300;China-Japan Friendship Hospital,Beijing 100029)

机构地区：[1]西北大学附属神木医院,陕西神木719300 [2]中日友好医院,北京100029

出　　处：《世界中西医结合杂志》2023年第8期1616-1619,共4页World Journal of Integrated Traditional and Western Medicine

摘　　要：目的 观察补肾调冲方对薄型子宫内膜不孕患者子宫内膜厚度、内膜形态、子宫内膜血流的影响,以评估补肾调冲方改善薄型子宫内膜容受性的临床疗效。方法 选取2018年10月—2019年10月期间就诊于中日友好医院中医妇科门诊的薄型子宫内膜不孕症患者50例,采用随机数字表法分为对照组和试验组,每组各25例。对照组给予戊酸雌二醇治疗,试验组在对照组基础上予补肾调冲方治疗,均从月经周期第5天口服,连服21 d,21 d为1个疗程。治疗3个疗程后,观察比较两组患者治疗前后子宫内膜厚度、内膜形态[A型(三线型)、B型(均一的中等回声,宫腔中线可见)、C型(均质强回声,宫腔中线不可见)]、内膜血流指数[内膜下血流搏动指数(Pulse index,PI)和血流阻力指数(Resistant index,RI)]。结果 治疗后两组患者子宫内膜厚度较治疗前升高,差异有统计学意义(P<0.05)。且试验组高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者子宫内膜分型A型较治疗前升高,差异有统计学意义(P<0.05),B型和C型较治疗前,差异无统计学意义(P>0.05);且试验组A型明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者子宫内膜血流PI、RI指数较治疗前明显降低,差异有统计学意义(P<0.05);且试验组子宫内膜血流PI、RI指数与对照组比较,差异无统计学意义(P>0.05)。结论 补肾调冲方能够显著改善薄型子宫内膜不孕患者的子宫内膜厚度、内膜形态和子宫内膜血流参数,从而改善子宫内膜容受性。Objective To observe the effects of Bushen Tiaochong Prescription on endometrial thickness,morphology,and blood flow in patients with thin endometrium-induced infertility and evaluate its clinical efficacy in improving endometrial receptivity.Methods Fifty patients with thin endometrium-induced infertility who visited the Department of Traditional Chinese Medicine Gynecology at the China-Japan Friendship Hospital between October 2018 and October 2019 were selected and randomly divided into a control group and an experimental group,with 25 patients in each group.The control group received treatment with estradiol valerate,while the experimental group received Bushen Tiaochong Prescription in addition to the treatment in the control group.Both groups started treatment on the 5th day of the menstrual cycle and continued for 21 days,constituting one treatment course.After three treatment courses,the changes in endometrial thickness,endometrial morphology(type A:triple-line pattern;type B:uniform moderate echogenicity with a visible central line;type C:homogenous strong echogenicity with an invisible central line),and endometrial blood flow indicators[subendometrial pulsatility index(PI)and resistance index(RI)]were observed and compared between the two groups.Results After treatment,the endometrial thickness in both groups increased significantly compared to that before treatment(P<0.05),and the experimental group showed a higher increase than the control group(P<0.05).After treatment,the proportions of type A endometrial morphology increased significantly compared with those before treatment in both groups(P<0.05).However,there were no statistically significant differences in type B and type C proportions before and after treatment in both groups(P>0.05).Additionally,the proportion of type A endometrial morphology in the experimental group was significantly higher than that in the control group(P<0.05).After treatment,the subendometrial blood flow indicators(PI and RI)in both groups decreased significantly compared

关 键 词：薄型子宫内膜 补肾调冲方 子宫内膜容受性 

分 类 号：R271.14[医药卫生—中医妇科学]