小剂量氨氯地平及替米沙坦治疗高血压患者的临床效果分析  

Analysis of the clinical effect of low-dose amlodipine and telmisartan on patients with hypertension

作　　者：何丹[1] HE Dan(Zhongnan University of Economics and Law Hospital,Wuhan 430073,China)

机构地区：[1]中南财经政法大学医院,430073

出　　处：《中国实用医药》2023年第18期90-93,共4页China Practical Medicine

摘　　要：目的分析小剂量氨氯地平及替米沙坦治疗高血压患者的临床效果。方法980例高血压患者为研究对象,按照随机数字表法分为对照组和观察组,每组490例。对照组给予小剂量氨氯地平治疗,观察组在对照组基础上加服替米沙坦治疗。比较两组血压降低至正常水平的时间,治疗前后舒张压和收缩压、白天血压变异性、夜间血压变异性和24 h血压变异性,治疗效果,不良反应发生情况。结果观察组血压降低至正常的时间(6.24±1.25)d短于对照组的(8.56±1.45)d,差异有统计学意义(P<0.05)。治疗后,观察组白天收缩压变异性、白天舒张压变异性、夜间收缩压变异性、夜间舒张压变异性、24 h收缩压变异性、24 h舒张压变异性、舒张压、收缩压分别为(8.56±1.21)、(10.19±2.48)、(7.56±1.01)、(10.56±1.21)、(8.56±1.26)、(10.21±2.41)、(78.56±3.21)、(122.19±2.49)mm Hg(1 mm Hg=0.133 kPa),对照组分别为(9.78±1.68)、(12.21±2.67)、(8.57±1.23)、(11.56±2.56)、(10.71±1.65)、(13.24±2.61)、(85.72±4.53)、(140.14±2.12)mm Hg。两组舒张压和收缩压、白天血压变异性、夜间血压变异性和24 h血压(收缩压、舒张压)变异性均明显低于治疗前,且观察组舒张压和收缩压、白天血压变异性、夜间血压变异性和24 h血压(收缩压、舒张压)变异性均显著低于对照组,差异有统计学意义(P<0.05)。观察组总有效率97.96%高于对照组的92.86%,差异有统计学意义(P<0.05)。两组均出现头昏、腹泻、呕吐等不良反应。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论小剂量氨氯地平及替米沙坦治疗高血压患者的效果确切,可有效控制患者血压水平,改善患者的血压变异性,且安全性高,值得推广。Objective To analyze the clinical effect of low-dose amlodipine and telmisartan on patients with hypertension.Methods A total of 980 patients with hypertension were divided into control group and observation group according to the random numerical table,with 490 cases in each group.The control group was treated with low-dose amlodipine,and the observation group was treated with telmisartan on the basis of the control group.Both groups were compared in terms of time of blood pressure decreased to normal,diastolic blood pressure and systolic blood pressure before and after treatment,daytime blood pressure variability,nighttime blood pressure variability and 24-h blood pressure variability,therapeutic effect,and adverse reactions.Results The time of blood pressure decreased to normal in the observation group was(6.24±1.25)d,which was shorter than that of(8.56±1.45)d in the control group,and the difference was statistically significant(P<0.05).After treatment,in the observation group,the daytime systolic blood pressure variability,daytime diastolic blood pressure variability,nighttime systolic blood pressure variability,24-h systolic blood pressure variability,24-h diastolic blood pressure variability,diastolic blood pressure,and systolic blood pressure were(8.56±1.21),(10.19±2.48),(7.56±1.01),(10.56±1.21),(8.56±1.26),(10.21±2.41),(78.56±3.21),and(122.19±2.49)mm Hg(1 mm Hg=0.133 kPa),and those of the control group were(9.78±1.68),(12.21±2.67),(8.57±1.23),(11.56±2.56),(10.71±1.65),(13.24±2.61),(85.72±4.53),and(140.14±2.12)mm Hg.After treatment,the diastolic blood pressure,systolic blood pressure,daytime blood pressure variability,nighttime blood pressure variability and 24-h blood pressure(systolic blood pressure and diastolic blood pressure)variability in both groups were lower than those before treatment in this group;the diastolic blood pressure,systolic blood pressure,daytime blood pressure variability,nighttime blood pressure variability and 24-h blood pressure(systolic blood pressure and diasto

关 键 词：高血压 氨氯地平 替米沙坦 血压变异性 

分 类 号：R544.1[医药卫生—心血管疾病]