地屈孕酮联合醋酸甲羟孕酮治疗围绝经期异常子宫出血患者的临床疗效观察  

Observation on clinical efficacy of dydrogesterone combined with medroxyprogesterone acetate in the treatment of perimenopausal patients with abnormal uterine bleeding

作　　者：胡青 HU Qing(Women's Health Department,Qufu Maternal and Child Health and Family Planning Service Center,Qufu 273100,China)

机构地区：[1]山东省曲阜市妇幼保健计划生育服务中心妇女保健科,273100

出　　处：《中国实用医药》2023年第18期118-121,共4页China Practical Medicine

摘　　要：目的分析地屈孕酮联合醋酸甲羟孕酮治疗围绝经期异常子宫出血患者的临床疗效。方法262例围绝经期异常子宫出血患者,随机分成对照组与研究组,各131例。对照组接受地屈孕酮治疗,研究组接受地屈孕酮联合醋酸甲羟孕酮治疗。比较两组异常子宫出血控制情况、治疗前后性激素水平及不良反应发生情况。结果治疗前,两组促黄体生成素(LH)、雌二醇(E2)、促卵泡刺激素(FSH)水平比较,差异无统计学意义(P>0.05)。治疗后,两组LH、E2、FSH水平均较本组治疗前显著下降,且研究组LH、E2、FSH水平分别为(6.18±1.73)mIU/ml、(12.55±2.47)pg/ml、(7.83±1.85)mIU/ml,均明显低于对照组的(7.92±1.96)mIU/ml、(14.79±3.08)pg/ml、(10.01±2.24)mIU/ml,差异有统计学意义(P<0.05)。研究组异常子宫出血控制总有效率97.71%显著高于对照组的83.97%,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论围绝经期异常子宫出血患者采用地屈孕酮联合醋酸甲羟孕酮治疗能显著提高临床疗效,有效控制出血,并显著改善性激素水平,同时不会增加药物不良反应,具有较好的安全性,值得推广。Objective To analyze the clinical efficacy of dydrogesterone combined with medroxyprogesterone acetate in the treatment of perimenopausal patients with abnormal uterine bleeding.Methods A total of 262 perimenopausal patients with abnormal uterine bleeding were randomly divided into control group and study group,with 131 cases in each group.The control group was treated with desdrogesterone,and the study group was treated with desdrogesterone and medroxyprogesterone acetate.The control of abnormal uterine bleeding,sex hormone levels before and after treatment,and the occurrence of adverse reactions were compared between the two groups.Results Before treatment,there was no statistically significant difference in the levels of luteinizing hormone(LH),estradiol(E2)and follicle-stimulating hormone(FSH)between the two groups(P>0.05).After treatment,the levels of LH,E2 and FSH decreased significantly in both groups when compared with those before treatment in this group;the levels of LH,E2 and FSH in the study group were(6.18±1.73)mIU/ml,(12.55±2.47)pg/ml and(7.83±1.85)mIU/ml,which were significantly lower than those of(7.92±1.96)mIU/ml,(14.79±3.08)pg/ml and(10.01±2.24)mIU/ml in the control group;the differences were statistically significant(P<0.05).The total effective rate of abnormal uterine bleeding in the study group was 97.71%,which was higher than that of 83.97%in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Dydrogesterone combined with medroxyprogesterone acetate can significantly improve the clinical efficacy of perimenopausal patients with abnormal uterine bleeding,effectively control the bleeding,and significantly improve the level of sex hormones,while not increasing the adverse drug reactions.It has high safety,and is worth promoting.

关 键 词：异常子宫出血 地屈孕酮 醋酸甲羟孕酮 围绝经期 

分 类 号：R711[医药卫生—妇产科学]