长时间血液透析对尿毒症患者钙磷代谢及血压的影响  

The effects of long-term hemodialysis on calcium-phosphorus metabolism and blood pressure in uremia patients

作　　者：刘倩[1] 蒲萌萌 杨凯 张风超 霍鹏飞[3] 李红石[3] LIU Qian;PU Mengmeng;YANG Kai;ZHANG Fengchao;HUO Pengfei;LI Hongshi(Department of Nephrology,Xingtai People’s Hospital,Hebei,Xingtai 054001,China;Emergency Department,Xingtai People’s Hospital,Hebei,Xingtai 054001,China;Blood Purification Room,Xingtai People’s Hospital,Hebei,Xingtai 054001,China)

机构地区：[1]河北省邢台市人民医院肾脏内科,河北邢台054001 [2]河北省邢台市人民医院急诊科,河北邢台054001 [3]河北省邢台市人民医院血液净化室,河北邢台054001

出　　处：《中国医药科学》2023年第17期170-173,共4页China Medicine And Pharmacy

基　　金：河北省邢台市重点研发计划自筹项目(2022ZC109)。

摘　　要：目的 研究长时间血液透析对尿毒症患者钙磷代谢及血压的影响。方法 选取2018年3月至2021年3月在邢台市人民医院进行维持性血液透析的尿毒症患者100例,采用随机数表法分为研究组(长时间血液透析组)和对照组(常规血液透析组,n=50),对比两组患者治疗前后的血钙、血磷、甲状旁腺激素(PTH)水平及收缩压,观察两组患者治疗过程中的并发症,评价长时间血液透析对尿毒症患者的血钙、血磷、PTH及血压的影响及安全性。结果 治疗3个月后两组患者的血磷水平均有所下降(P <0.05),且研究组下降更为明显(P <0.05);两组患者治疗前后的血钙、PTH的水平比较,差异无统计学意义(P> 0.05);治疗后研究组患者的收缩压明显下降(P <0.01)。对照组患者的收缩压与治疗前比较,差异无统计学意义(P> 0.05);治疗过程中研究组出现高血压、低血压及其他并发症的例数较对照组明显减少(P <0.05)。结论 长时间血液透析能够明显降低尿毒症患者的血磷水平,降低尿毒症患者的血压,并且使血压更稳定,安全性更好。Objective To investigate the effects of long-term hemodialysis on calcium-phosphorus metabolism and blood pressure in uremia patients.Methods A total of 100 uremia patients who underwent maintenance hemodialysis at Xingtai People’s Hospital from March 2018 to March 2021 were divided into a study group(long-term hemodialysis group)and a control group(conventional hemodialysis group,n=50)using a random digit table method.The blood calcium,blood phosphorus,parathyroid hormone(PTH)levels,and systolic blood pressure of the two groups of patients before and after treatment were compared,and the complications during the treatment process were observed,and the effect and safety of long-term hemodialysis on blood calcium,phosphorus,PTH,and blood pressure in uremia patients were evaluated.Results After 3 months of treatment,the blood phosphorus levels of both groups of patients decreased(P<0.05),with a more significant decrease in the study group(P<0.05);There was no statistically significant difference in the levels of blood calcium and PTH between the two groups of patients before and after treatment(P>0.05);After treatment,the systolic blood pressure of the study group patients significantly decreased(P<0.01),while the systolic blood pressure of the control group patients showed no statistically significant difference compared to before treatment(P>0.05);During the treatment process,the number of cases of hypertension,hypotension,and other complications in the study group was significantly reduced compared to the control group(P<0.05).Conclusion Long-term hemodialysis can significantly reduce the blood phosphorus levels and blood pressure of uremia patients,making blood pressure more stable and safer.

关 键 词：长时间血液透析 尿毒症 钙 磷 血压 

分 类 号：R692.5[医药卫生—泌尿科学]