拮抗剂方案治疗高龄卵巢低反应患者的临床效果  

Clinical efficacy of antagonist therapy in patients of advanced maternal age with a poor ovarian response

作　　者：刘婷婷[1] 邓琼[1] 林卓惠 LIU Tingting;DENG Qiong;LIN Zhuohui(Gynecology Department,Zhuhai Center for Maternal and Child Health Care,Guangdong,Zhuhai 519000,China)

机构地区：[1]广东省珠海市妇幼保健院妇科,广东珠海519000

出　　处：《中国医药科学》2023年第18期90-93,共4页China Medicine And Pharmacy

基　　金：广东省珠海市科技计划项目(ZH2202200062HJL)。

摘　　要：目的探讨拮抗剂方案治疗高龄卵巢低反应(POR)患者的临床效果及对结局的影响。方法将珠海市妇幼保健院生殖中心2020年1月至2021年3月收治的150例高龄POR患者随机分为对照组(n=75,给予微刺激方案治疗)与观察组(n=75,给予拮抗剂方案治疗),比较分析两组患者促排卵、胚胎发育及妊娠等情况。结果①在促排卵方面,观察组患者卵巢对促性腺激素(Gn)使用量、使用时间及人绒毛膜促性腺激素(HCG)日雌二醇(E2)均明显高于对照组(P<0.05)。观察组HCG日促黄体生成素(LH)明显小于对照组(P<0.05)。②在胚胎发育方面,观察组患者可利用胚胎数、优质胚胎数、获卵数均明显多于对照组(P<0.05)。两组患者未获卵率,差异无统计学意义(P>0.05)。③在妊娠情况方面,观察组移植胚胎个数低于对照组(P<0.05)。两组患者的胚胎着床率、临床妊娠率比较,差异无统计学意义(P>0.05)。结论在高龄POR治疗中,微刺激方案与拮抗剂方案的应用效果均十分显著,拮抗剂方案可以提高可利用胚胎数、优质胚胎数等,高龄患者卵泡发育更均匀,妊娠结局反馈移植胚胎个数少,临床应用价值高,效果好,可基于高龄患者实际情况,科学选择治疗方案。Objective To explore the clinical efficacy of antagonist therapy in patients of advanced maternal age with a poor ovarian response(POR)as well as its impact on outcomes.Methods A total of 150 patients of advanced maternal age with a POR admitted to the Reproductive Center of Zhuhai Center for Maternal and Child Health Care from January 2020 to March 2021 were randomly divided into a control group(n=75,treated with microstimulation)and an observation group(n=75,treated with antagonist).The ovulation induction,embryonic development,and pregnancy status of the two groups were compared and analyzed.Results(1)In terms of ovulation induction,the amount and duration of gonadotropin(Gn),as well as daily estradiol(E2)of human chorionic gonadotropin(HCG)used in the ovaries of the observation group,were significantly higher than those in the control group(P<0.05).The amount and duration of luteinizing hormone(LH)used in the observation group were significantly lower than those in the control group(P<0.05).(2)In terms of embryonic development,the number of available embryos,high-quality embryos,and oocytes retrieved in the observation group were significantly higher than those in the control group(P<0.05).There was no statistically significant difference in the rate of non-retrieved oocytes between the two groups(P>0.05).(3)In terms of pregnancy status,the number of embryos transferred in the observation group was smaller than that in the control group(P<0.05).There were no statistically significant differences in embryo implantation rate and clinical pregnancy rate of the two groups(P>0.05).Conclusion In the treatment of patients of advanced maternal age with a POR,both microstimulation and antagonist regimens have significant efficacy.Antagonists can increase the number of available embryos,high-quality embryos,etc.The follicular development of patients of advanced maternal age is more uniform,and the number of embryos transferred through pregnancy outcome feedback is less.The clinical application value is high,and the eff

关 键 词：高龄 拮抗剂方案 卵巢低反应 结局 

分 类 号：R714.8[医药卫生—妇产科学]