顺铂治疗鼻咽癌耐药机制与逆转策略研究进展  

Advanced Research Progress of Cisplatin Resistance Mechanism and Reversal Strategy in Nasopharyngeal Carcinoma Chemotherapy

作　　者：韩蜜[1,2] 伍梦玲 龙远雄 邓桂明 HAN Mi;WU Mengling;LONG Yuanxiong;DENG Guiming(Department of Pharmacy,Hunan Cancer Hospital,Changsha 410013,China;Department of Scientific Research,the First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410007,China)

机构地区：[1]湖南省肿瘤医院药学部,长沙410013 [2]湖南中医药大学第一附属医院科研部,长沙410007

出　　处：《医药导报》2023年第10期1529-1533,共5页Herald of Medicine

基　　金：湖南省自然科学基金资助项目(2022JJ70104);湖南省中医药管理局科研计划项目(2021162);湖南省教育厅科研项目(21B0372);长沙市科技局自然科学基金资助项目(kq2014219)。

摘　　要：鼻咽癌是临床常见的恶性肿瘤,放射治疗和化学治疗(化疗)是治疗鼻咽癌的常见手段,以顺铂为主的联合化疗是中晚期鼻咽癌的基础治疗方案之一,然而在治疗过程中肿瘤细胞耐药成为鼻咽癌治疗的一大瓶颈。顺铂是一种细胞周期非特异阻断药物,通过破坏DNA合成和有丝分裂而诱导鼻咽癌细胞凋亡。该文主要从DNA损伤修复能力的增强、药物外排增加及摄取减少、药物体内灭活、凋亡调控基因表达失控等方面阐述鼻咽癌顺铂耐药的机制,并收集近年来文献中报道逆转鼻咽癌顺铂耐药的策略进行综述,为寻找有效干预目标及靶标分子来增加肿瘤细胞对顺铂的敏感性。Nasopharyngeal carcinoma is a common malignant tumor in clinic.Radiotherapy and chemotherapy are common methods for the treatment of nasopharyngeal carcinoma.Cisplatin-based combination chemotherapy is one of the basic treatment options for middle and advanced stage nasopharyngeal carcinoma.However,tumor cell drug resistance has become a significant bottleneck in treating nasopharyngeal carcinoma during the treatment process.Cisplatin,a cell cycle nonspecific blocker,induces apoptosis in nasopharyngealcarcinoma cells by disrupting DNA synthesis and mitosis.In this paper,the mechanism of cisplatin resistance in nasopharyngeal carcinoma was elaborated from the aspects of enhanced DNA damage repair ability,increased drug efflux and decreased uptake,drug inactivation in vivo,and uncontrolled expression of apoptosis-regulated genes.In addition,the strategies for reversing cisplatin resistance in nasopharyngeal carcinoma reported in recent years were collected and reviewed,to find effective intervention targets and target molecules to increase the sensitivity of tumor cells to cisplatin.

关 键 词：顺铂 鼻咽癌 耐药机制 逆转策略 

分 类 号：R979.1[医药卫生—药品] R739.62[医药卫生—药学]