围绝经期高脂血症患者ABCB1基因多态性与阿托伐他汀调脂疗效的关系  

Relationship Between ABCB1 Gene Polymorphisms and Lipid-regulating Efficacy of Atorvastatin in Patients with Perimenopausal Hyperlipidemia

作　　者：刘慧[1] 常宇峰 李静[1] 王颖 LIU Hui;CHANG Yufeng;LI Jing;WANG Ying(Department of Pharmacy,Beijing Haidian Hospital,Beijing 100080,China;Department of Cardiovascular Medicine,Beijing Haidian Hospital,Beijing 100080,China)

机构地区：[1]北京市海淀医院药剂科,北京100080 [2]北京市海淀医院心血管内科,北京100080

出　　处：《医药导报》2023年第10期1544-1547,共4页Herald of Medicine

基　　金：北京市海淀医院青年项目(KYQ2019006)。

摘　　要：目的探讨围绝经期高脂血症患者ABCB1(2677T>G)、ABCB1(3435C>T)基因多态性分布及其与阿托伐他汀降脂疗效的相关性。方法采用荧光原位杂交方法,检测80例围绝经期高脂血症患者ABCB1(2677T>G)、ABCB1(3435C>T)基因型分布;入选患者每晚服用阿托伐他汀20 mg,连续用药8周后,检测用药前后血脂水平,评价降脂疗效。结果在80例入选患者中,ABCB1(2677T>G)、ABCB1(3435C>T)基因突变频率分别为62%和60%,该基因分布符合Hardy-Weinberg平衡。携带ABCB1(2677GG)型患者对低密度脂蛋白胆固醇(LDL-C)的调节作用显著高于同一位点的其他基因型,而其他血脂指标未见相关性。ABCB1(3435C>T)各基因型患者间血脂变化差异无统计学意义。结论携带ABCB12677GG基因型的患者接受阿托伐他汀治疗时,降脂疗效较佳,但ABCB1(3435C>T)位点多态性可能与阿托伐他汀降脂疗效无关。Objective To investigate the distribution of ABCB1(2677T>G)and ABCB1(3435C>T)gene polymorphisms in patients with perimenopausal hyperlipidemia and their correlation with the lipid-lowering efficacy of atorvastatin.Methods The genotypes distribution of ABCB1(2677T>G)and ABCB1(3435C>t)in 80 patients with perimenopausal hyperlipidemia were detected by fluorescence in situ hybridization;The enrolled patients took atorvastatin 20 mg every night.After continuous treatment for eight weeks,the blood lipid levels before and after the treatment were measured to evaluate the lipid-lowering effect.Results Among the 80 selected patients,the mutation frequencies of ABCB1(2677T>G)and ABCB1(3435C>T)genes were 62%and 60%,respectively.The gene distribution was consistent with Hardy Weinberg equilibrium.The regulation of LDL-C in patients with ABCB12677GG was significantly higher than that of other genotypes at the same locus,but there was no correlation between other blood lipid markers.There was no significant difference in blood lipid changes among patients with ABCB1(3435C>T)genotypes.Conclusion Patients with ABCB12677GG genotype have better lipid-lowering effect when treated with atorvastatin,but ABCB1(3435C>T)polymorphism may not be related to the lipid-lowering effect of atorvastatin.

关 键 词：阿托伐他汀 围绝经期 高脂血症 基因多态性 

分 类 号：R972.6[医药卫生—药品]