32种常用中成药钾含量测定及其在慢性肾脏病中的应用分析  

Determination of Potassium Content in 32 Commonly Used Chinese Patent Medicines and Analysis of Its Application in Chronic Kidney Disease

作　　者：陈祝君 边原[1,2] 杜姗 易小清[1,2] 崔小娇 胡为博 刘心霞 CHEN Zhujun;BIAN Yuan;DU Shan;YI Xiaoqing;CUI Xiaojiao;HU Weibo;LIU Xinxia(Department of Pharmacy,Sichuan Academy of Medical Sciences&Sichuan Provincial People’s Hospital,School of Medicine,University of Electronic Science and Technology of China,Chengdu 610072,China;Personalized Drug Therapy Key Laboratory of Sichuan Province,School of Medicine,University of Electronic Science and Technology of China,Chengdu 610072,China;Qilu Medical University,Zibo 255300,China)

机构地区：[1]四川省医学科学院·四川省人民医院药学部,成都610072 [2]电子科技大学医学院个体化药物治疗四川省重点实验室,成都610072 [3]齐鲁医药学院,淄博255300

出　　处：《医药导报》2023年第10期1548-1553,共6页Herald of Medicine

基　　金：国家重点研发计划(2020YFC2005506);四川省科技厅重点研发计划(2021YFS0387);四川省科技厅重点研发计划(2019YFS0514);四川省卫生健康委员会科研课题(19PJ269);四川省人民医院博士基金课题(2015BS04)。

摘　　要：目的检测常用中成药的钾含量,为慢性肾脏病(CKD)患者安全使用中成药提供参考。方法选取32种常用中成药,微波消解后,采用电感耦合等离子体发射光谱法检测钾的含量,计算每日药源性钾摄入量,评估对CKD患者的影响。结果32种中成药都有钾的检出,含量各有差异。其中成方制剂含钾量较高,单味制剂次之,提取物制剂最低;每日药源性钾摄入量超过100 mg的中成药有8种,包括CKD患者常用的尿毒清颗粒等。结论中成药潜在的钾负荷可能使CKD患者钾摄入超标,升高血清钾,增加高钾血症风险,应引起重视。Objective To determine the potassium content of commonly used Chinese patent medicines(CPMs)and to provide a reference for the safe use of CPMs in patients with chronic kidney disease(CKD).Methods A total of 32 commonly used CPMs were selected and detected for potassium content by inductively coupled plasma-optical emission spectrometry after microwave ablation,and the daily drug-derived potassium intake was calculated.The effect on CKD patients was evaluated.Results Potassium was detected in all 32 CPMs with varying levels.Among them,the prescription preparation has the highest potassium content,followed by single flavor preparation,and the extract preparation has the lowest potassium content.Eight CPMs had a daily pharmacogenic potassium intake of more than 100mg,including uremic clearance granules,which are commonly used by CKD patients.Conclusion It is noteworthy that the potential potassium load of CPMs might cause the intake of potassium to exceed the standards in CKD patients to raise serum potassium and increase the risk of hyperkalemia.

关 键 词：中成药 钾含量 慢性肾脏病 高钾血症 

分 类 号：R289[医药卫生—方剂学] R927.2[医药卫生—中药学]