类风湿性关节炎联合检测免疫球蛋白及抗CCP抗体和类风湿因子的诊断价值研究  

Diagnostic value of combined detection of immunoglobulin,anti-CCP antibody and rheumatoid factor in rheumatoid arthritis

作　　者：李良[1] 王闪[1] 王宗仁[1] 郭建政[1] LI Liang;WANG Shan;WANG Zong-ren;GUO Jian-zheng(Department of Laboratory Science,Xinxiang Central Hospital,Xinxiang 453000,Henan,China)

机构地区：[1]新乡市中心医院检验科,河南新乡453000

出　　处：《医药论坛杂志》2023年第15期106-109,共4页Journal of Medical Forum

基　　金：河南省医学科技攻关计划省部共建项目(SBGJ202002326)。

摘　　要：目的 研究免疫球蛋白、抗CCP抗体以及类风湿因子三项联合检测用于类风湿性关节炎(rheumatoid arthritis, RA)诊断的临床价值。方法 纳入49例2020年3月-2022年3月新乡市中心医院收治的类风湿性关节炎患者作为研究组,再纳入同期接收入院非类风湿性关节炎患者49例作为参照组,对两组患者均开展免疫球蛋白、抗CCP抗体以及类风湿因子检测,对比单项检测与联合检测结果,分析三项指标联合检测的疾病诊断效能。结果 研究组的类风湿因子检出阳性率(79.59%)显著高于参照组(18.36%),差异有统计学意义(P<0.05);研究组的抗CCP抗体检出阳性率(69.38%)及免疫球蛋白检出阳性率均明显高于参照组(P<0.05);免疫球蛋白、抗CCP抗体以及类风湿因子三项指标单独检测的灵敏度(73.46%、69.38%、79.59%)、特异度(61.53%、53.33%、50.00%)与三项联合检测对比均明显降低,差异有统计学意义(P<0.05)。结论 与免疫球蛋白、类风湿因子以及抗CCP抗体单项检测对比,三项联合检测在类风湿性关节炎诊断中有着更好的灵敏度与特异度,从而提升疾病检出率,可以作用为临床诊断疾病的有效辅助手段,有很高的应用价值。Objective To study the clinical value of immunoglobulin,anti-CCP antibody and rheumatoid factor com-bined detection in the diagnosis of rheumatoid arthritis(RA).Methods Totally 49 cases rheumatoid arthritis patients,from March 2020 to March 2022,in my hospital were selected as study group,and in the same period to receive admis-sion in 49 cases of as control group,were carried out on two groups of patients immune globulin,anti CCP antibody and rheumatoid factor testing,comparing single detection with joint detection results,the diagnostic efficacy of the combined detection of three indexes was analyzed.Results The positive rate of rheumatoid factor in the study group(79.59%)was significantly higher than that in the control group(18.36%),and the difference was statistically significant(P<0.05).The anti-CCP positive rate(69.38%)and immunoglobulin positive rate in the study group were signifi-cantly higher than those in the control group(P<0.05).The sensitivity(73.46%,69.38%,79.59%)and specifici-ty(61.53%,53.33%,50.00%)of immunoglobulin,anti-CCP antibody and rheumatoid factor were significantly de-creased compared with the three combined tests,and the difference was statistically significant(P<0.05).Conclusion Compared with the single detection of immunoglobulin,rheumatoid factor and anti-CCP antibody,the three combined tests have better sensitivity and specificity in the diagnosis of rheumatoid arthritis,thus improving the de-tection rate of the disease,and can act as an effective assistant means for clinical diagnosis of disease,with high application value.

关 键 词：免疫球蛋白 抗CCP抗体 类风湿因子 联合检测 类风湿性关节炎 

分 类 号：R446.6[医药卫生—诊断学]