白细胞介素-6-572C-G基因多态性与小儿复杂型热性惊厥及症状发作后脑损伤关系临床研究  

Relationship between IL-6 gene polymorphism and complex febrile seizures and post seizure brain damage in children

作　　者：武文娟 韩伟[1] WU Wenjuan;HAN Wei(Children’s Hospital,Shaanxi Provincial People’s Hospital,Xi’an 710068,China)

机构地区：[1]陕西省人民医院儿童病院,陕西西安710068

出　　处：《陕西医学杂志》2023年第10期1371-1374,共4页Shaanxi Medical Journal

基　　金：陕西省重点研发计划项目(2021SF-197)。

摘　　要：目的:探究白细胞介素-6-572C-G(IL-6-572C-G)基因多态性与小儿复杂型热性惊厥(CFS)及发作后脑损伤的相关性。方法:收集150例热性惊厥FS患儿和50例健康志愿小儿(对照组)为对象,依据FS发病类型将其分为单纯组和复杂组。测定比较各组IL-6-572C-G基因型频率和等位基因表达频率。比较CFS发作后脑损伤患儿与无脑损伤患儿IL-6-572C-G基因型频率和等位基因表达频率差异,分析影响CFS发作后脑损伤形成的危险因素。结果:复杂组CC基因型频率和C等位基因频率明显低于单纯组,单纯组明显低于对照组(均P<0.05),复杂组GG基因型频率和G等位基因频率高于单纯组,单纯组高于对照组(均P<0.05),复杂组和单纯组CG基因型频率均高于对照组(均P<0.05)。CFS发作后脑损伤患儿CC基因型频率和C等位基因频率明显低于无脑损伤者,GG基因型频率和G等位基因频率高于无脑损伤者(均P<0.05)。Logistic回归分析显示,IL-6基因型CG+GG是CFS发作后脑损伤形成的危险因素(P<0.05)。结论:CFS患儿IL-6基因型异于单纯型FS,主要以CG+GG基因型为主,且与患儿发作后脑损伤形成有关,是CFS发作后脑损伤形成的危险因素之一。Objective:To investigate the relationship between interleukin 6-572C-G(IL-6-572C-G)gene polymorphism and complex febrile convulsion(CFS)in children and brain injury after seizures.Methods:A total of 150 children with FS caused by febrile seizures and 50 healthy volunteers(control group)were collected as subjects,and children with FS were divided into simple group and complex group based on the type of FS onset.The genotype frequency and allele expression frequency of IL-6-572C-G in each group were measured and compared.The differences of IL-6 genotype frequency and allele expression frequency between children with brain injury after CFS attack and children without brain injury were compared,and the risk factors affecting the formation of brain injury after CFS attack were analyzed.Results:The CC genotype frequency frequency and C allele frequency in the complex group were lower than those in the simple group,and those in the simple group were lower than those in the control group(all P<0.05).The GG genotype frequency frequency and G allele frequency in the complex group were higher than those in the simple group,and those in the simple group were higher than those in the control group(all P<0.05).The CG genotype frequency frequency in the complex group and the simple group were higher than those in the control group(all P<0.05).The CC genotype frequency and C allele frequency of children with brain injury after CFS attack were lower than those without brain injury,and the GG genotype frequency and G allele frequency were higher than those without brain injury(all P<0.05).Logistic regression analysis showed that IL-6 genotype CG+GG was a risk factor for brain injury formation after CFS onset(P<0.05).Conclusion:The IL-6 genotype in children with CFS is different from that of simple FS,mainly characterized by CG+GG genotype,and is related to the formation of brain injury after CFS attacks.It is one of the risk factors for the formation of brain injury after CFS attacks.

关 键 词：热性惊厥 复杂型 脑损伤 白细胞介素-6 基因多态性 

分 类 号：R729[医药卫生—儿科]