TI-RADS分类联合血清半乳糖凝集素-3鉴别甲状腺结节的临床价值  

Clinical value of TI-RADS category combined with serum Galectin-3 in differentiating thyroid nodules

作　　者：云永子 陶阳[1] 冯岚[1] 王春红 林琳 YUN Yongzi;TAO Yang;FENG Lan;WANG Chunhong;LIN Lin(Department of Function,Sanya Central Hospital,Hainan Third People’s Hospital,Hainan 572000,China)

机构地区：[1]三亚中心医院海南省第三人民医院功能科,海南省三亚市572000

出　　处：《临床超声医学杂志》2023年第9期755-758,共4页Journal of Clinical Ultrasound in Medicine

摘　　要：目的探讨TI-RADS分类联合血清半乳糖凝集素-3(Galectin-3)鉴别良恶性甲状腺结节的临床价值。方法选取我院经病理证实的甲状腺结节患者389例(均为单发),其中良性206例,恶性183例,均行常规超声检查并进行TI-RADS分类;检测患者血清Galectin-3并比较其差异。绘制受试者工作特征(ROC)曲线分析TI-RADS分类、血清Galectin-3单独及联合应用鉴别良恶性甲状腺结节的诊断效能。结果良恶性甲状腺结节直径、成分、回声、纵横比、边缘、钙化等方面比较差异均有统计学意义(均P<0.05)。TI-RADS分类检出3类、4A类、4B类、4C类及5类结节分别为27、78、135、81、68例,其中良性240例,恶性149例。良恶性甲状腺结节血清Galectin-3分别为(1.30±0.34)ng/ml、(2.88±1.38)ng/ml,差异有统计学意义(P<0.05)。ROC曲线分析显示,TI-RADS分类联合血清Galectin-3鉴别良恶性甲状腺结节的曲线下面积为0.909,高于TI-RADS分类和血清Galectin-3单独应用(0.862、0.850),差异均有统计学意义(均P<0.05)。结论TI-RADS分类联合血清Galectin-3能准确鉴别良恶性甲状腺结节,具有较好的临床应用价值。Objective To explore the clinical value of TI-RADS category combined with serum Galectin-3 in differentiating benign and malignant thyroid nodules.Methods A total of 389 patients with thyroid nodules confirmed by pathology in our hospital were selected,of which 206 cases were benign and 183 cases were malignant,all of which were single.All patients underwent routine ultrasound examination and TI-RADS category,and the serum Galectin-3 was detected,the difference was compared.Receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic efficacy of TIRADS category,serum Galectin-3 applied alone and in combination to differentiate benign and malignant thyroid nodules.Results There were significant differences in maximum diameter,composition,echo,aspect ratio,margin and calcification between benign and malignant thyroid nodules(all P<0.05).There were 27,78,135,81,68 nodules in TI-RADS 3,4A,4B,4C and 5 category,respectively.Including 240 cases were benign and 149 cases were malignant.Serum Galectin-3 of benign and malignant thyroid nodules were(1.30±0.34)ng/ml and(2.88±1.38)ng/ml,there was significant difference(P<0.05).ROC curve analysis showed that the area under the curve of TI-RADS category combined with serum Galectin-3 in differentiating benign and malignant thyroid nodules was 0.909,which was higher than that of TI-RADS category and serum Galectin-3 applied alone(0.862,0.850),and the differences were statistically significant(both P<0.05).Conclusion TI-RADS category combined with serum Galectin-3 can accurately differentiate benign and malignant thyroid nodules,which has good clinical application value.

关 键 词：超声检查 TI-RADS GALECTIN-3 甲状腺结节 良恶性 

分 类 号：R445.1[医药卫生—影像医学与核医学] R736.1[医药卫生—诊断学]