基于数据挖掘探讨治疗湿热中阻型糖尿病肾病用药规律  

Data Mining Based on Exploring the Medication Pattern in Treating Damp-Heat-Mediated Diabetic Nephropathy

作　　者：陈丹 甘德成 Chen Dan;Gan Decheng(Gansu University of Chinese Medicine,Lanzhou 730000,China;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃省中医院,甘肃兰州730050

出　　处：《亚太传统医药》2023年第9期178-182,共5页Asia-Pacific Traditional Medicine

摘　　要：目的:基于数据挖掘探讨治疗湿热中阻型糖尿病肾病的用药规律。方法:收集整理2021年2月-2022年2月甘肃省中医院糖尿病科甘德成主任门诊及住院部处方共计192首,采用SPSS Modeler 18.0和SPSS Statistics 26.0对药物进行功效、性味、归经统计,关联分析、聚类分析等。结果:共涉及中药209味,总频次2923次,高频药物有葛根、黄芪、黄连等;药味以甘、辛、苦为主,药性以温、寒、平为主;核心药对有桑叶+知母+葛根,土茯苓+桑叶+葛根等;聚类分析将药物分为7组。结论:甘德成主任医师秉承家族中医学术思想,结合多年临床经验及中医基础理论,认为糖尿病中医辨证以虚实为主,三焦常变为辅,病机以气阴两虚为本,阴虚更甚,湿浊化热为变,治则以益气滋阴、利湿化浊为主,辨证施治,随症加减。Objective:To explore the medication pattern based on data mining for the treatment of diabetic nephropathy with damp-heat middle blockage.Methods:A total of 192 prescriptions were collected and collated from February 2021 to February 2022 in the outpatient and inpatient departments of the Department of Diabetes,Gansu Provincial Hospital of Traditional Chinese Medicine,Gansu Province,and SPSS Modeler 18.0 and SPSS Statistics 26.0 were used to perform efficacy,flavor and ascription statistics,association analysis and cluster analysis on drugs.Results:A total of 209 herbal medicines were involved,with a total frequency of 2923 times.High-frequency drugs included Pueraria lobata,Astragalus,Huanglian,etc.;the taste was mainly sweet,pungent and bitter,and the properties were mainly warm,cold and flat;the core pairs included Mulberry leaf,Zhi Mu,Pueraria lobata,Tu Fuling,Mulberry leaf,Pueraria lobata,etc.cluster analysis divided the drugs into 7 groups.Conclusion:Gan Decheng,Chief Physician,adhering to the family's academic thought of Chinese medicine,combined with years of clinical experience and the foundation of Chinese medicine,believes that the Chinese medical evidence of diabetes mellitus is based on deficiency,supplemented by the constant change of the three jiao,the pathogenesis of the disease is based on the deficiency of both Qi and Yin,the deficiency of Yin is even worse,dampness and turbidity into heat,the treatment is to benefit Qi and nourish Yin,dampness and turbidity as the main treatment,identify the evidence and add and subtract according to the symptoms.

关 键 词：湿热中阻型 糖尿病肾病 用药规律 

分 类 号：R256.5[医药卫生—中医内科学]