转录因子在基因可变剪接中的作用  

Role of transcription factors in alternative splicing of genes

作　　者：翁雅娟 特日格乐 宋代玲 王国庆 蔺雅楠 芒来[1] 李蓓[1] WENG Yajuan;Terigele;SONG Dailing;WANG Guoqing;LIN Ya’nan;Manglai;LI Bei(Inner Mongolia Key Laboratory of Equine Science Research and Technology Innovation/Scientific Observing and Experimental Station of Equine Genetics,Breeding and Reproduction,Ministry of Agriculture and Rural Affairs/Equine Research Center,College of Animal Science,Inner Mongolia Agricultural University,Hohhot 010018,China)

机构地区：[1]内蒙古农业大学动物科学学院内蒙古自治区马属动物科学研究与技术创新重点实验室/农业农村部马属动物遗传育种与繁殖科学观测实验站/内蒙古农业大学马属动物研究中心,内蒙古呼和浩特010018

出　　处：《黑龙江畜牧兽医》2023年第17期37-43,54,共8页Heilongjiang Animal Science And veterinary Medicine

基　　金：内蒙古农业大学青年教师科研能力提升专项(BR230152);内蒙古农业大学动物科学学院高水平成果培育专项(QT202216);国家自然科学基金项目(31960657);内蒙古自治区科技重大专项(2020ZD0004)。

摘　　要：转录因子大多在细胞中表达,并参与调控机体内很多重要的细胞生物过程,是生物体内不可或缺的组成成分,其可以通过各种机制和不同程度的特异性调控可变剪接过程,从而促进基因表达。可变剪接与生物体的发育、细胞凋亡及疾病的发生关系密切,而前体mRNA(Pre-mRNA)的可变剪接是生物体转录组及蛋白质组多样性的重要成因,并且可以精准地完成受顺式调控元件、表观信息等综合因素的调控。因此,文章综述了转录因子在基因可变剪接中的作用,以期为细胞凋亡、疾病发生等生物过程的研究提供理论基础。Transcription factors are mostly expressed in cells,and are involved in the regulation of many important cellular biological processes in the body.They are indispensable components in the body.They can regulate the variable splicing process through various mechanisms and different degrees of specificity,thus promoting gene expression.Alternative splicing is closely related to the development of organisms,cell apoptosis and the occurrence of diseases,and the alternative splicing of Pre-mRNA is an important cause of the diversity of organisms’transcriptome and proteome and can be accurately regulated by cis-regulatory elements,apparent information and other comprehensive factors.Therefore,this paper reviewed the role of transcription factors in gene alternative splicing,in order to provide a theoretical basis for the study of cell apoptosis,disease occurrence and other biological processes.

关 键 词：转录因子 可变剪接 基因 调控 癌症 精子生成 

分 类 号：Q344.13[生物学—遗传学]