漳州市地区类孟买血型血清学及FUT1基因分析  

Analysis on Serology and FUT1 Gene of Para-Bombay Phenotype in Zhangzhou Area

作　　者：林艺璇 唐聪海 LIN Yi-Xuan;TANG Cong-Hai(Department of Blood Transfusion,Zhangzhou Affiliated Hospital of Fujian Medical University,Zhangzhou 363000,Fujian Province,China)

机构地区：[1]福建医科大学附属漳州市医院输血科,福建漳州363000

出　　处：《中国实验血液学杂志》2023年第5期1496-1500,共5页Journal of Experimental Hematology

摘　　要：目的:探讨类孟买血型血清学表现及分子机制。方法:采用血清学方法鉴定类孟买血型的血清学表现,PCR扩增检测类孟买血型的分子机制。结果:通过血清学和PCR检测出18例类孟买血型,Am^(h)5例,Bm^(h)4例,Om^(h)10例。产生抗HI抗体8例。结论:血型血清学联合分子生物学方法可准确鉴定类孟买血型。类孟买血型个体输血时应采取特殊输血策略,以避免溶血性反应的发生。Objective:To investigate blood group serological manifestations and molecular mechanism of para-Bombay phenotype.Methods:The serological manifestations of para-Bombay phenotype was identified by serological assay.Molecular mechanism of para-Bombay phenotype was detected by PCR amplification.Results:Eighteen cases of para-Bombay phenotype were detected through serology and PCR,including 5 cases of Am^(h),4 cases of Bm^(h),and 10 cases of Om^(h).Eight cases produced anti-HI antibody.Conclusions:Blood group serology combined with molecular biology can accurately identify para-Bombay phenotype.Special transfusion strategy should be adopted for individual with para-Bombay phenotype to avoid hemolytic reactions.

关 键 词：类孟买血型 FUT1 输血策略 

分 类 号：R457.11[医药卫生—治疗学]