骨涎蛋白在破骨细胞分化和骨吸收中的研究进展  

Research progress of bone sialoprotein in osteoclast differentiation and bone resorption

作　　者：曾俊铭 贺小宁 ZENG Jun-ming;HE Xiao-ning(Department of Stomatology,the Second Affiliated Hospital of Hainan Medical University,Haikou 570100,China)

机构地区：[1]海南医学院第二附属医院口腔科,海南海口570100

出　　处：《海南医学院学报》2023年第18期1425-1429,共5页Journal of Hainan Medical University

基　　金：国家自然科学基金(81260275)。

摘　　要：骨涎蛋白是一个重要的非胶原细胞外间质蛋白,具有促进骨形成以及诱导骨吸收的功能,可刺激成骨细胞分化,并诱导矿化组织的出现。骨的吸收由一个复杂的分子网络控制,而骨涎蛋白可以促进破骨细胞分化与骨吸收,同时它也与一系列恶性肿瘤的转移息息相关。目前认为破骨细胞是骨吸收的唯一细胞,在骨骼的形成以及后期的发育改建中发挥重要作用。骨质疏松症和牙周病都是因过度骨吸收而引起的。本文将对骨涎蛋白在破骨细胞分化和骨吸收中的生物学功能进行总结,并探讨通过调控破骨细胞从而预防和治疗骨质疏松和牙周病等骨吸收相关疾病的进展。Bone sialoprotein(BSP)is an important non⁃collagen extracellular matrix protein that promotes bone formation and induces bone resorption.BSP is secreted by odontoblasts,and plays an important role in cementum,alveolar bone formation and mineralization,and periodontal function.Bone resorption is controlled by a complex molecular network,and BSP can promote osteoclast differentiation and bone resorption.It is also associated with the metastasis of a range of malignancies.Osteoclasts are thought to be the only cells involved in bone resorption and play an important role in bone formation and late developmental remod⁃eling.Osteoporosis and periodontal disease are caused by excessive bone resorption.This article will summarize the osteoclasts dif⁃ferentiation,the biological function of bone resorption,and explore the progress of the prevention and treatment of the related bone resorption diseases such as osteoporosis and periodontal disease through the regulation of osteoclasts.

关 键 词：骨涎蛋白 骨吸收 破骨细胞 骨质疏松 牙周病 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]