基于卤虫模型的麻醉剂评价方法  

Evaluation Methods of Anesthetics Based on Artemia spp.Model

作　　者：赵理翔 张雨凡 莫非 蒋怡伶 桑妤琪 王娟[2] 俞志明[1] ZHAO Lixiang;ZHANG Yufan;MO Fei;JIANG Yiling;SANG Yuqi;WANG Juan;YU Zhiming(College of Life and Environmental Sciences,Hangzhou Normal University,Hangzhou 311121,China;Department of Clinical Laboratory,Tongde Hospital of Zhejiang Province,Hangzhou 310012,China)

机构地区：[1]杭州师范大学生命与环境科学学院,浙江杭州311121 [2]浙江省立同德医院医学检验科,浙江杭州310012

出　　处：《杭州师范大学学报（自然科学版）》2023年第5期491-496,共6页Journal of Hangzhou Normal University(Natural Science Edition)

基　　金：国家自然科学基金项目(31200913);浙江省自然科学基金项目(LY19C020002);杭州市科技局项目(4105C5062000611);杭州师范大学本科生创新能力提升工程项目(CX2022135).

摘　　要：卤虫(Artemia spp.)在麻醉剂药效评价中有较大应用前景.从麻醉剂的剂量分析、毒理学分析、行为学分析、生物标志物分析等方面,梳理了以卤虫作为麻醉剂评价模型的具体应用,构建了基于卤虫模型的候选麻醉剂筛选及麻醉效力评价的工作模型,以期为新的麻醉剂筛选及评价提供思路.Artemia spp.has great application prospects in the evaluation of anesthetic efficacy.This study summarized the specific applications of Artemia spp.as an anesthetic evaluation model from the aspects of dose analysis,toxicology analysis,behavioral analysis,and biomarker analysis,etc.Based on the Artemia spp.model,a working model for candidate anesthetic screening and efficacy evaluation was constructed.The results provided ideas for new anesthetic screening and evaluation.

关 键 词：卤虫 麻醉剂 评价方法 芯片实验室 

分 类 号：R614.1[医药卫生—麻醉学]