维生素D干预治疗对体外受精-胚胎移植妊娠结局的影响  

Influence of the vitamin D on pregnancy outcomes of in vitro fertilization-embryo transfer

作　　者：习艳霞[1] 王慧春[1] 刘慧文[1] XI Yanxia;WANG Huichun;LIU Huiwen(Haidian Maternal and Child Health Care Hospital,Beijing,100088)

机构地区：[1]北京市海淀区妇幼保健院,100088

出　　处：《中国计划生育学杂志》2023年第9期2049-2053,共5页Chinese Journal of Family Planning

基　　金：北京市海淀区卫生健康发展科研培育计划(HP2022-05-103001)。

摘　　要：目的:探讨维生素D干预治疗与体外受精-胚胎移植(IVF-ET)妊娠结局的相关性。方法:选择2021年6月-2022年6月本院因输卵管因素实施IVF-ET助孕患者200例,检测血清25-(OH)D水平并分为维生素D充足组(n=42,≥30 ng/ml)与不足/缺乏组(n=158,<30 ng/ml),再将不足/缺乏组随机数字表法分为干预组(n=79,给予维生素D滴剂-胶囊型干预治疗),未干预组(n=79)不进行干预。比较干预组、未干预组、充足组临床资料、IVF-ET治疗情况、妊娠结局,Spearman相关性分析、二分类logistic回归分析影响IVF-ET妊娠结局因素。结果:未干预组、干预组、充足组血清25-(OH)D水平、获卵数、卵子成熟率、受精率、优质胚胎率均有差异(P<0.05),临床妊娠率未干预组(35.4%)、干预组(51.9%)、充足组(71.4)依次升高(P<0.05),临床妊娠组与非临床妊娠组年龄、血清25-(OH)D水平、移植日子宫内膜厚度、血清25-(OH)D是否充足、获卵数、卵子成熟率、受精率、优质胚胎率比较均有差异(P<0.05)。Spearman相关性分析,血清25-(OH)D水平与临床妊娠呈正相关(r=0.139,P=0.001);logistic回归分析,年龄、血清25-(OH)D水平、移植日内膜厚度、血清25-(OH)D充足均与临床妊娠有关(均P<0.05)。结论:血清25-(OH)D水平与IVF-ET妊娠结局有关,维生素D干预对改善IVF-ET妊娠结局有积极影响,能提高临床妊娠率。Objective:To investigate the correlation between the vitamin D for treating women after in vitro fertilization?embryo transfer(IVF-ET)and their pregnancy outcomes.Methods:From June 2021to June 2022,200women who had undergone IVF-ET assisted pregnancy due to fallopian tube factors were selected.The serum 25-(OH)D level of these women was measured.According to the serum 25-(OH)D level,these women were divided 42women with vitamin D level≥30ng/mL in group A and 158women with vitamin D level<30ng/mL in group B.The women in the group B were further divided into two groups according to the random number table method.And among them,79 women with treatment of vitamin D drops-capsule type were in group B1,and 79women without treatment of vitamin D drops-capsule type were in group B2.The clinical data,the situation of IVF-ET treatment,and the pregnancy outcomes of the women were compared among group B1,group B2,and group A.Spearman correlation analysis and binary Logistic regression analysis were used to identify the factors affecting the pregnancy outcomes of the women after IVF-ET.Results:There were significant differences in the serum 25-(OH)D level,the rates of oocytes retrieved,oocyte maturation,fertilization,and high-quality embryo of the women among group B2,group B1,and group A(P<0.05).The clinical pregnancy rate in group B2(35.4%),in group B1(51.9%),and in group A(71.4%)had increased gradually(P<0.05).There were significant differences in the age,the serum 25-(OH)D level,the endometrial thickness on the embryo transfer day,the sufficient serum 25-(OH)D or not,the number of oocytes retrieved,the oocyte maturation rate,the fertilization rate,and the high-quality embryo rate between the women with clinical pregnancy and the women without clinical pregnancy(P<0.05).Spearman correlation analysis showed that the serum 25-(OH)D level of the women was positively correlated with their clinical pregnancy situation(r=0.139,P=0.001).Logistic regression analysis showed that the age,the serum 25-(OH)D level,the endometrial th

关 键 词：体外受精-胚胎移植 维生素D 临床妊娠 相关性 

分 类 号：R714.8[医药卫生—妇产科学]