滋肾育胎丸治疗黄体功能不全所致复发性流产对患者子宫内膜容受性改善效果  

Efficacy of the endometrial receptivity improvement of Zishen yutai pill for treating patients with recurrent abortion caused by luteal insufficiency

作　　者：郑维秀 肖丽珍 廖薇薇 邹婧 林元 黄乔 ZHENG Weixiu;XIAO Lizhen;LIAO Weiwei;ZOU Jing;LIN Yuan;HUANG Qiao(Hainan Western Central Hospital,Danzhou,Hainan Province,571799;Sanya People's Hospital of Hainan Province)

机构地区：[1]海南西部中心医院,儋州571799 [2]海南省三亚市人民医院

出　　处：《中国计划生育学杂志》2023年第9期2059-2062,共4页Chinese Journal of Family Planning

基　　金：海南省卫生健康行业科研项目(20A200528)。

摘　　要：目的:滋肾育胎丸治疗黄体功能不全所致复发性流产对患者子宫内膜容受性的影响。方法:以2019年6月-2021年3月本院收治的156例黄体功能不全所致复发性流产患者为研究对象,使用简单随机法分为联合组(n=52)、中药组(n=52)、对照组(n=52),对照组予以地屈孕酮片治疗、中药组使用滋肾育胎丸治疗、联合组在对照组基础联合滋肾育胎丸治疗。使用多模态超声评估患者子宫内膜容受性[子宫内膜厚度、内膜体积(EV)、血管血流指数(VFI)]差异,比较治疗前后子宫内膜形态差异,分析妊娠结局差异并比较治疗期间不良反应。结果:治疗后,子宫内膜厚度、EV、VFI 3组均较治疗前上升且联合组高于中药组和对照组(P<0.05),中药组与对照组无差异(P>0.05);子宫内膜形态3组均较治疗前发生显著变化且联合组优于中药组和对照组(P<0.05),中药组与对照组无差异(P>0.05);临床妊娠率联合组(59.6%)高于中药组(32.7%)、对照组(38.4%)(P<0.05),中药组与对照组无差异(P>0.05),再流产、早产率3组无差异(P>0.05);治疗期间3组不良反应无差异(P>0.05)。结论:联合滋肾育胎丸治疗黄体功能不全所致复发性流产对患者子宫内膜容受性改善效果更佳,临床妊娠提高。Objective:To evaluate the effects of Zishen yutai pill for treating patients with recurrent abortion caused by luteal insufficiency on their endometrial receptivity.Methods:156patients with recurrent abortion caused by luteal insufficiency between June 2019and March 2021were enrolled as the study subjects,and they were divided into three groups(52cases in each group)by using simple randomization method.The patients in group A were treated with dydrogesterone tablets combined with Zishen yutai pill,the patients in group B were treated with Zishen yutai pill,and the patients in group C were treated with dydrogesterone tablets.Multimodal ultrasound was used to evaluate the differences of the endometrial receptivity,such as endometrial thickness,endometrial volume(EV),and vascular flow index(VFI)of the patients in the three groups.The differences of the endometrial morphology of the patients in the three groups were explored before and after treatment.The differences of the pregnancy outcomes and the occurrence of adverse reactions of the patients during treatment in the three groups were analyzed.Results:The values of endometrial thickness,EV,and VFI of the patients in the three groups after treatment had increased significantly,and which of the patients in group A was significantly higher than that of the patients in group B and that of the patients in group C(P<0.05),but which of the patients had no significant difference between group B and group C(P>0.05).The endometrial morphology of the patients in the three groups after treatment had changed significantly,which of the patients in group A was significantly better than that of the patients in group B and in group C(P<0.05),but which of the patients had no significant difference between group B and group C(P>0.05).The clinical pregnancy rate(59.6%)of the patients in group A was significantly higher than that(32.7%)of the patients in group B and that(38.4%)of the patients in group C(P<0.05),but which of the patients had no significant difference between group B a

关 键 词：复发性流产 黄体功能不全 滋肾育胎丸:子宫内膜容受性 临床妊娠 

分 类 号：R714.21[医药卫生—妇产科学]