前列腺炎患者精液质量、精子运动与前列腺液M-CSF、NF-kB水平的相关性  

Correlation between the semen quality and sperm movement of patients with prostatitis and their macrophage colony-stimulating factor and nuclear transcription factor-kB levels in prostatic fluid

作　　者：李洪超 吴元才 唐永泽 罗顺文 LI Hongchao;WU Yuancai;TANG Yongze;LUO Sunwen(Sichuan Friendship Hospital,Chengdu,Sichuan Province,610066)

机构地区：[1]四川友谊医院,成都610066

出　　处：《中国计划生育学杂志》2023年第9期2190-2194,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨前列腺炎患者精液质量、精子运动与前列腺液巨噬细胞集落刺激因子(M-CSF)、核转录因子-kB(NF-kB)水平的相关性。方法:选择本院2019年5月-2022年12月诊治的前列腺炎患者300例为病例组,根据疾病严重程度分为轻度组、中度组和重度组,同期体检健康男性95例为对照组,检测两组精液质量、精子运动参数和前列腺液M-CSF、NF-kB水平并分析各指标间相关性。结果:病例组精液量、pH值、精子浓度、精子总活力、存活率、前向运动精子百分率均低于对照组,液化时间、M-CSF、NF-kB水平均高于对照组,且轻度组、中度组、重度组精液量、液化时间、M-CSF、NF-kB水平依次升高,pH值、精子浓度、精子总活力、存活率、前向运动精子百分率依次降低;精液量、液化时间分别与M-CSF、NF-kB水平呈正相关,pH值、精子浓度、存活率、精子总活力、前向运动精子百分率分别与M-CSF、NF-kB水平呈负相关(均P<0.05)。结论:前列腺炎患者精液质量参数、精子运动参数、NF-kB和MSCF水平存在异常表达,且精液质量、精子运动与NF-kB和MSCF均具有相关性。Objective:To study the correlation between the semen quality and sperm motion parameter of patients with prostatitis and their levels of macrophage colony-stimulating factor(M-CSF)and nuclear transcription factor-kB(NF?kB)in prostatitis patients.Methods:300patients with prostatitis diagnosed and treated in hospital from May 2019to December 2022were selected in study and divided into group A(patients with mild prostatitis),group B(patients with moderate prostatitis),group C(patients with severe prostatitis).95healthy men who came to hospital for physical examination during the same period were selected in control group.The semen quality,the values of sperm motion parameter,and the levels of M-CSF and NF-kB in prostatic fluid of the men in the study group and control group were detected.The correlation between the semen quality and values of sperm motion parameter of the patients and their levels of M-CSF and NF-kB in prostatic fluid was analyzed.Results:The semen volume,the pH value,the sperm concentration,the total sperm motility,the sperm survival rate,and the percentage of forward motile sperm of the patients in the study group were significantly lower than those of the men in the control group,while the semen liquefaction time,and the levels of M-CSF and NF-kB of the patients in the study group were significantly higher than those of the men in the control group(P<0.05).The semen volume,the semen liquefaction time,and the levels of M-CSF and NF-kB of the patients in group A,in group B,and in group C had increased gradually.The pH value,the sperm concentration,the total sperm motility,the sperm survival rate,and the percentage of forward motile sperm of the patients in group A,in group B,and in group C had decreased gradually.The semen volume and the sperm liquefaction time of the patients in the study group were positively correlated with their M-CSF and NF-kB levels,while the pH value,the sperm concentration,the sperm survival rate,the total sperm motility,and the percentage of forward motile sperm of the pat

关 键 词：前列腺炎 精液质量 精子运动 巨噬细胞集落刺激因子 核转录因子-KB 相关性 

分 类 号：R697.33[医药卫生—泌尿科学]