致命鹅膏的研究进展  

Research progress of Amanita exitialis

作　　者：梁嘉祺 章轶哲 李海蛟[1] 孙承业[1] Liang Jiaqi;Zhang Yizhe;Li Haijiao;Sun Chengye(National Institute of Occupational Health and Poison Control,Chinese Center for Disease Control and Prevention,Beijing 100050,China)

机构地区：[1]中国疾病预防控制中心职业卫生与中毒控制所,北京100050

出　　处：《中国急救医学》2023年第9期689-695,共7页Chinese Journal of Critical Care Medicine

摘　　要：致命鹅膏最早发现于我国广东,是我国蘑菇中毒事件中最常见的剧毒蘑菇之一,因含有鹅膏肽类毒素,可以造成急性肝损害型中毒,引起相关食物中毒事件已有73起。本研究系统分析了致命鹅膏的生物学特征、毒素检测、毒素基因组学、中毒事件流行病学及毒理学等方面的研究历程和最新进展,以期为该种剧毒蘑菇中毒的有效防控和精准救治提供科学依据。Amanita exitialis was initially discovered in Guangdong province of China.It is one of the most common highly toxic mushrooms involved in mushroom poisoning incidents in China.Due to the presence of amanitin peptides,the ingestion of this mushroom can lead to acute liver injury-type poisoning,resulting in 73 documented cases of food poisoning incidents.In this study,the biological characteristics,toxin detection,toxin genomics,epidemiological analysis of poisoning incidents,and toxicology of Amanita exitialis were systematically analyzed,aiming to provide new insights for the effective prevention and control and precise treatment of the common lethal mushroom Amanita exitialis poisoning.

关 键 词：急性肝损害型 剧毒蘑菇 蘑菇中毒 毒理学 基因组学 

分 类 号：R595.6[医药卫生—内科学]