重组人干扰素α-2 a雾化吸入联合盐酸氨溴索治疗呼吸道合胞病毒感染所致支气管肺炎患儿的效果  

Effects of aerosol inhalation of recombinant human interferonα-2a combined with Ambroxol hydrochloride in treatment of children with bronchopneumonia caused by respiratory syncytial virus infection

作　　者：郑南花 ZHENG Nanhua(Department of Pediatrics of Shaxian District General Hospital,Sanming 365500 Fujian,China)

机构地区：[1]沙县区总医院儿科,福建三明365500

出　　处：《中国民康医学》2023年第17期80-82,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察重组人干扰素α-2a雾化吸入联合盐酸氨溴索治疗呼吸道合胞病毒(RSV)感染所致支气管肺炎患儿的效果。方法:选取2020年1月至2023年2月该院收治的120例RSV感染所致支气管肺炎患儿进行前瞻性研究,按照随机数字表法将其分为对照组和研究组各60例。对照组口服盐酸氨溴索片治疗,研究组在对照组基础上联合重组人干扰素α-2a雾化吸入治疗。比较两组临床疗效,治疗前后凝血功能指标[血小板计数(PLT)、D-二聚体(D-D)]水平、血清炎性因子[降钙素原(PCT)、C反应蛋白(CRP)]水平,临床症状消失时间,以及不良反应发生率。结果:研究组治疗总有效率为90.00%(54/60),高于对照组的75.00%(45/60),差异有统计学意义(P<0.05);治疗后,两组血清PLT、D-D水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组血清CRP、PCT水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);研究组咳嗽消失时间和退热时间均短于对照组,差异有统计学意义(P<0.05);两组治疗期间均未见明显药物不良反应。结论:重组人干扰素α-2a雾化吸入联合盐酸氨溴索治疗RSV感染所致支气管肺炎患儿可提高治疗总有效率,加快临床症状消失,改善凝血功能,降低炎性因子水平,效果优于单纯盐酸氨溴索治疗。Objective:To observe effects of aerosol inhalation of recombinant human interferonα-2a combined with Ambroxol hydrochloride in treatment of children with bronchopneumonia caused by respiratory syncytial virus(RSV)infection.Methods:A prospective study was conducted on 120 children with bronchopneumonia cause d by RSV infection admitted to this hospital from January 2020 to Febru ary 2023.They were divided into control group and study group according to the random number table method,60 cases in each.The control group was treated with Ambroxol hydrochloride,while the study group was treated with aerosol inhalation of recombinant human interferonα-2a on the basis of that of the control group.The clinical efficacy,the coagulation function index levels[platelet count(PLT),D-dimer(D-D)],the serum inflammatory factor levels[procalcitonin(PCT),C-reactive protein(CRP)]before and after the treatment,the disappearance time of clinical symptoms,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 90.00%(54/60),which was higher than 75.00%(45/60)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of PLT and D-D in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of serum CRP and PCT in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The disappearance time of cough and the antipyretic time in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).However,no obvious drugrelated adverse reactions were found in the two groups during the treatment.Conclusions:Aerosol inhalation of recombinant human interferonα-2a combin

关 键 词：重组人干扰素Α-2A 盐酸氨溴索 呼吸道合胞病毒 支气管肺炎 凝血功能 炎性因子 不良反应 

分 类 号：R725.6[医药卫生—儿科]