血清AST、ChE、PON1联合检测对急性有机磷农药中毒患者预后的预测价值  

Predictive value of combined detection of serum AST,ChE and PON1 in prognosis of patients with acute organophosphorus pesticide poisoning

作　　者：刘平洋 王丽霞 范小勇 LIU Pingyang;WANG Lixia;FAN Xiaoyong(Xinxiang Central Hospital,Emergency Department of Fourth Clinical College of Xinxiang Medical College,Xinxiang 453000 Henan,China)

机构地区：[1]新乡市中心医院新乡医学院第四临床学院急诊科,河南新乡453000

出　　处：《中国民康医学》2023年第17期124-126,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:分析血清天门冬氨酸氨基转移酶(AST)、胆碱酯酶(ChE)、对氧磷酶1(PON1)联合检测对急性有机磷农药中毒(AOPP)患者预后的预测价值。方法:选取2020年5月至2022年8月该院收治的68例AOPP患者为研究对象,纳入研究组。另选取同期本院健康体检者68名为对照组。两组均检测血清AST、ChE、PON1水平,入院5 d后评估AOPP患者预后。采用受试者工作特征曲线(ROC)分析血清AST、ChE、PON1单项及联合检测在AOPP患者预后中的预测价值。结果:68例AOPP患者预后不良19例,占27.94%(19/68);预后良好49例。研究组血清AST水平高于对照组,ChE、PON1水平均低于对照组,差异有统计学意义(P<0.05);治疗24 h后,预后不良患者血清AST水平高于预后良好患者,ChE、PON1水平均低于预后良好患者,差异有统计学意义(P<0.05);ROC曲线分析结果显示,治疗24 h后血清AST、ChE、PON1联合检测的曲线下面积(AUC)>0.9,预测价值较高,且高于各单项检测。结论:血清AST、ChE、PON1联合检测预测AOPP患者预后的价值高于各单项检测。Objective:To analyze predictive value of combined detection of serum aspartate aminotransferase(AST),cholinesterase(ChE)and paraoxonase 1(PON1)in prognosis of patients with acute organophosphorus pesticide poisoning(AOPP).Methods:68 patients with AOPP admitted to the hospital from May 2020 to August 2022 were selected as the study subjects and included in the study group.Another 68 healthy subjects in this hospital during the same period were selected as the control group.The serum AST,ChE and PON1 levels were detected in both groups.The prognosis of the AOPP patients was evaluated 5 days after admission.The receiver operating characteristic curve(ROC)was used to analyze the predictive value of single and combined detection of serum AST,ChE and PON1 in the prognosis of the patients with AOPP.Results:There were 19 cases of poor prognosis in the 68 patients with AOPP,accounting for 27.94%(19/68).The prognosis was good in 49 cases.The serum AST level of the study group was higher than that of the control group,the levels of ChE and PON1 were lower than those of the control group,and the differences were statistically significant(P<0.05).After 24 hours of treatment,the serum AST level of the patients with poor prognosis was higher than that of the patients with good prognosis,the levels of ChE and PON1 were lower than those of the patients with good prognosis,and the differences were statistically significant(P<0.05).The ROC curve analysis showed that the AUC of combined detection of serum AST,ChE and PON1 after 24 h of treatment was greater than 0.9,and the predictive value was higher than that of each single detection.Conclusions:The value of combined detection of serum AST,ChE and PON1 in the prediction the prognosis of the AOPP patients is higher than that of each single detection.

关 键 词：急性有机磷农药中毒 天门冬氨酸氨基转移酶 胆碱酯酶 对氧磷酶1 预后 预测 价值 

分 类 号：R595[医药卫生—内科学]