CK-MB、MYO、hs-cTnT对脓毒症患者心肌损伤的诊断意义  

Diagnostic significance of CK-MB,MYO and hs-cTnT for myocardial injury in patients with sepsis

作　　者：吴泳桦 姚力偀 苏维 刘都 WU Yong-hua;YAO Li-ying;SU Wei;LIU Du(Department of Medical Laboratory,Mianyang Central Hospital Affiliated to Medical College of University of Electronic Science and Technology of China,Mianyang Sichuan 621000,China;Department of Health Services,Mianyang Central Hospital Affiliated to Medical College of University of Electronic Science and Technology of China,Mianyang Sichuan 621000,China)

机构地区：[1]电子科技大学医学院附属绵阳市中心医院医学检验科,四川绵阳621000 [2]电子科技大学医学院附属绵阳市中心医院医务科,四川绵阳621000

出　　处：《局解手术学杂志》2023年第9期813-816,共4页Journal of Regional Anatomy and Operative Surgery

基　　金：四川省卫生健康委员会医学科技项目(21PJ176)。

摘　　要：目的探讨血清肌酸激酶同工酶MB(CK-MB)、肌红蛋白(MYO)、高敏肌钙蛋白T(hs-cTnT)检测对脓毒症患者心肌损伤的诊断价值。方法选取我院收治的132例脓毒症患者,根据患者是否存在心肌损伤分为心肌损伤组(50例)和非心肌损伤组(82例),根据脓毒症患者心肌损伤严重程度分为轻度组(33例)和重度组(17例)。采用电化学发光法检测患者血清CK-MB、MYO、hs-cTnT水平;采用受试者工作特征(ROC)曲线分析血清CK-MB、MYO、hs-cTnT水平对脓毒症患者心肌损伤的诊断价值,计算灵敏度、特异度、曲线下面积(AUC)。结果心肌损伤组患者血清CK-MB、MYO、hs-cTnT水平均高于非心肌损伤组(P<0.05)。重度组患者血清CK-MB、MYO、hs-cTnT水平均高于轻度组(P<0.05)。ROC曲线结果显示,血清CK-MB、MYO、hs-cTnT联合检测诊断脓毒症患者心肌损伤的灵敏度和AUC均高于单独检测(P<0.05)。结论脓毒症心肌损伤患者血清CK-MB、MYO、hs-cTnT水平升高,且心肌重度损伤患者以上指标水平均高于轻度损伤患者,检测血清CK-MB、MYO、hs-cTnT均对脓毒症患者心肌损伤有一定的诊断价值,而三者联合检测诊断价值更高。Objective To investigate the diagnostic values of serum creatine kinase-MB(CK-MB),myoglobin(MYO)and hypersensi⁃tive cardiac troponin T(hs-cTnT)detection for myocardial injury in patients with sepsis.Methods A total of 132 patients with sepsis admitted to our hospital were selected,and they were divided into the myocardial injury group(50 cases)and non-myocardial injury group(82 cases)according to whether the patients had myocardial injury,and sepsis patients with myocardial injury were divided into the mild group(33 cases)and severe group(17 cases)according to their severity.The levels of serum CK-MB,MYO and hs-cTnT of patients were detected by electrochemiluminescence assay.The diagnostic values of serum CK-MB,MYO and hs-cTnT levels on myocardial injury in patients with sepsis were analyzed by the receiver operating characteristic(ROC)curve,and the sensitivity,specificity and area under the curve(AUC)were calculated.Results The levels of serum CK-MB,MYO and hs-cTnT in the myocardial injury group were higher than those in the non-myocardial injury group(P<0.05).The levels of serum CK-MB,MYO and hs-cTnT in the severe group were higher than those in the mild group(P<0.05).ROC curve results showed that the sensitivity and AUC of combined detection of serum CK-MB,MYO and hs-cTnT to diagnose myocardial injury in patients with sepsis were higher than those of individual detection(P<0.05).Conclusion The levels of serum CK-MB,MYO and hs-cTnT are increased in sepsis patients with myocardial injury,and the levels of the above indicators in patients with severe myocardial injury were higher than those in patients with mild myocardial injury.The detections of serum CK-MB,MYO and hs-cTnT have certain diagnostic value for myocardial injury in patients with sepsis,and the diagnostic value of the combined detection is higher.

关 键 词：肌酸激酶同工酶MB 肌红蛋白 高敏肌钙蛋白T 脓毒症 心肌损伤 

分 类 号：R459.7[医药卫生—急诊医学]