近红外光响应药物缓释的纳米纤维素基水凝胶的制备  

Preparation of NIR Light-controlled Drug Release Based on Cellulose Nanocrystals

作　　者：刘小红[1] 沈娟莉 Altaf.H.BASTA 付时雨[1] LIU Xiaohong;SHEN Juanli;Altaf H BASTA;FU Shiyu(State Key Laboratory of Pulp and Paper Engineering,South China University of Technology,Guangzhou 510640,China;National Research Centre,Cario,Egypt)

机构地区：[1]华南理工大学制浆造纸工程国家重点实验室,广东广州510640 [2]埃及国家研究中心,埃及开罗

出　　处：《造纸科学与技术》2023年第4期1-7,49,共8页Paper Science & Technology

基　　金：国家重点研发计划项目(2021YFE0104500);国家自然科学基金项目(22078114)。

摘　　要：纤维素纳米晶体(CNCs)因具有良好的生物相容性,高弹性模量,高机械强度和刚度,高比表面积和高长径比等优异的性质受到了广泛的关注。采用传统的自由基聚合,以N-异丙基丙烯酰胺(NIPAAm)为单体,聚多巴胺纳米颗粒(PDA-NPs)作为功能性交联剂以及CNCs作为增强剂制备出的具有近红外光响应的水凝胶。FTIR和XPS等测试验证了PNIPAAm/CNCs&PDA复合水凝胶的成功合成。SEM测试表明PNIPAAm/CNCs&PDA复合水凝胶具有大的孔隙率,且PDA-NPs在复合水凝胶中分布均匀。此外,该复合水凝胶能够在近红外光(NIR)的刺激下加速释放药物,表现出明显的近红外光响应性,且细胞相容性实验表明该复合水凝胶具有优异的生物相容性。因此,此纳米纤维素水凝胶可应用于生物医学领域。Cellulose nanocrystals(CNCs)have received widespread attention due to their excellent properties such as good biocompatibility,high elastic modulus,high mechanical strength and stiffness,high specific surface area,and high aspect ratio.In this paper,the hydrogels with NIR photoresponsive properties were prepared by conventional free radical polymerization using Nisopropyl acrylamide(NIPAAm)as the monomer,polydopamine nanoparticles(PDA-NPs)as the functional cross-linking agent as well as CNCs as the reinforcing agent.The successful synthesis of the composite hydrogels with PNIPAAm/CNCs&PDA was verified by tests such as FTIR and XPS.SEM tests showed that the PNIPAAm/CNCs&PDA composite hydrogel had large porosity,and the PDANPs were uniformly distributed in the composite hydrogel.In addition,the composite hydrogel was able to accelerate the drug release under the stimulation of near-infrared light(NIR),showing obvious NIR light responsiveness.The cytocompatibility experiments demonstrated that the composite hydrogel had excellent biocompatibility.Therefore,this nanocellulose hydrogel can be used in biomedical applications.

关 键 词：纤维素纳米晶体 近红外光响应水凝胶 药物释放 生物医学 

分 类 号：TQ427.26[化学工程]