The role of small non-coding RNAs(sncRNAs)in male infertility:A scoping review  

作　　者：Cakir Kaya Hacer Eroglu Onur 

机构地区：[1]Department of Molecular Biology and Genetics,Faculty of Science,Bilecik Seyh Edebali University,Bilecik,Turkey

出　　处：《Asian pacific Journal of Reproduction》2023年第5期201-210,共10页亚太生殖杂志（英文版）

摘　　要：Objective:To give a brief overview of the field of epigenetics and the potential predictive power that small non-coding RNA(sncRNA)may hold in relation to improving the treatment and diagnosis of male infertility.Methods:PRISMA-ScR was used as the scoping review guideline for this investigation.All article data here have been accessed from MEDLINE–PubMed,Science Direct,EBSCO,Scopus,Sage Journals,and Google Scholar.The terms"small non coding RNA,male,infertility,miRNA,sperm"were used in the search between 2015 and 2023.Results:The study comprised 35 publications in total.Several sncRNAs,miR-155,miR-16,miR-196,miR-525-3p,miR-891 were found to be effective in regulating the mechanism of spermatozoa processing in the infertility of men.sncRNA can be used as a biomarker of male infertility.Conclusions:sncRNAs can act as biomarkers for the diagnosis of reproductive diseases.Actually,by recognizing sncRNAs and their mechanisms,a new way to treat infertile men would be paved.The functional annotation of sncRNAs in spermatogenesis is still in its infancy but has enormous potential.This is despite the fact that many potential sncRNAs have been found to date with the use of cutting-edge technology and publicly accessible sncRNA annotation tools.

关 键 词：Male infertility MIRNA Small untranslated RNA sncRNAs SPERM Next-generation sequencing Real-time PCR 

分 类 号：R69[医药卫生—泌尿科学]