人参皂苷对心肌缺血再灌注损伤的保护作用及机制研究进展  

Research Progress of the Protective Effect and Mechanism of Ginsenosides on Myocardial Ischemia Reperfusion Injury

作　　者：范致星 黄逸凡 杨简 Fan Zhixing;Huang Yifan;Yang Jian(Department of Medical Record,Yichang Central People's Hospital,The First College of Clinical Medical Science,China Three Gorges University,Yichang 443003,China;Institute of Cardiovascular Diseases,China Three Gorges University,Yichang 443003,China;Hubei Clinical Research Center for Ischemic Cardiovascular Disease,Yichang 443003,China)

机构地区：[1]三峡大学第一临床医学院[宜昌市中心人民医院]病案科,湖北宜昌443003 [2]三峡大学心血管病研究所,湖北宜昌443003 [3]湖北省缺血性心血管疾病临床医学研究中心,湖北宜昌443003

出　　处：《巴楚医学》2023年第3期110-114,共5页Bachu Medical Journal

基　　金：国家自然科学基金青年基金项目(No:81800258);湖北省卫健委科研项目(No:WJ2023M150);湖北省自然科学基金一般面上项目(No:2023AFB609)。

摘　　要：人参是一种化学成分复杂、生物活性广泛且药理作用独特的传统药物。人参皂苷是人参的主要活性成分,随着现代分离技术的发展,已分离出包括Rb1、Rb2、Rc、Rg1、Re、Rd、Rg3和Rh2在内的超过150种人参皂苷单体。近年来,人参皂苷被证实可通过清除氧自由基,减少钙超载,减轻炎症反应和细胞凋亡而抑制心肌缺血再灌注损伤(MIRI)。本文查阅近年来国内外相关文献,就人参皂苷抗MIRI的作用及机制进行综述。Panax ginseng is a traditional medicine with complex chemical components,extensive biological activities and unique pharmacological effects.Ginsenoside is the main active component of ginseng.With the development of modern separation technology,more than 150 kinds of ginsenoside monomers including Rb1,Rb2,Rc,Rg1,Re,Rd,Rg3 and Rh2 have been isolated.In recent years,ginsenosides have been proved to inhibit myocardial ischemia-reperfusion injury(MIRI)by scavenging oxygen free radicals,reducing calcium overload,alleviating inflammatory reaction and cell apoptosis.In this paper,we reviewed the effects and mechanism of ginsenosides on MIRI by consulting the relevant literature in recent years.

关 键 词：人参皂苷 心肌缺血再灌注损伤 保护作用 

分 类 号：R542.2[医药卫生—心血管疾病]