生物碱类化合物降压作用及其机制研究进展  

Research Progress on Antihypertensive Effect and Mechanism of Alkaloid Compounds

作　　者：成志云[1] 解李祥 白如玉[1] 刁勇[1] CHENG Zhiyun;XIE Lixiang;BAI Ruyu;DIAO Yong(School of Medicine,Huaqiao University,Quanzhou 362021,China)

机构地区：[1]华侨大学医学院,福建泉州362021

出　　处：《华侨大学学报（自然科学版）》2023年第5期550-557,共8页Journal of Huaqiao University(Natural Science)

基　　金：国家自然科学基金资助项目(20141ZA003);福建省药理学会科技联合项目(2021FJYL007)。

摘　　要：作为一种广泛存在于植物体内的活性化合物,生物碱已被证明有显著的降压作用,且作用机制也逐渐被阐明.通过查阅近年来的相关文献,综述各种来源的生物碱在降压领域的研究进展,阐述生物碱在治疗高血压方面的潜力及今后研究需要关注的问题.结果表明:生物碱降压作用显著,作用机制逐渐明确,有望成为治疗高血压的潜力药物.As an active compound widely presented in plants,alkaloids have been shown to have significant antihypertensive effects,and the mechanism of action is gradually being elucidated.By reviewing relevant literature in recent years,research progress of various sources of alkaloids in the field of hypertension is reviewed,and the potential of alkaloids in the treatment of hypertension and the issues that need to be addressed in future research are elucidated.The results show that alkaloids have a significant antihypertensive effect,and the mechanism of action is gradually becoming clear,which is expected to become a potential drug for treating hypertension.

关 键 词：高血压 生物碱 作用机制 降压作用 

分 类 号：R284.2[医药卫生—中药学]