脉冲直流电喷雾电离质谱法现场快速检测尿液中28种芬太尼类新精神活性物质  

Rapid detection of 28 kinds of fentanyl new psychoactive substances in urine by pulsed direct current electrospray ionization mass spectrometry

作　　者：时巧翠[1] 傅佳宇 陈金媛 姚森 谢伟宏[3] SHI Qiaocui;FU Jiayu;CHEN Jinyuan;YAO Sen;XIE Weihong(Key Laboratory of Drug Prevention and Control Techology of Zhejiang Province,Zhejiang Police College,Hangzhou 310053,China;College of Environment,Zhejiang University of Technology,Hangzhou 310014,China;Institute of Criminal Science and Technology,Hangzhou Municipal Public Security Bureau,Hangzhou 310004,China)

机构地区：[1]浙江省毒品防控技术研究重点实验室,浙江警察学院,杭州310053 [2]浙江工业大学环境学院,杭州310014 [3]杭州市公安局刑事科学技术研究所,杭州310004

出　　处：《分析试验室》2023年第8期1026-1032,共7页Chinese Journal of Analysis Laboratory

基　　金：“十三五”国家重点研发计划课题(2018YFC0807404);浙江省基础公益研究计划项目(LGF18B050002);2022年国家级大学生创新创业训练计划(202211483029)资助。

摘　　要：开发了脉冲直流电喷雾电离质谱(pulsed-dc-ESI-MS)法用于尿液中28种芬太尼类新精神活性物质的快速检测。尿液经乙酸乙酯液液萃取后取上清液,采用pulsed-dc-ESI进样。结果表明,该方法的检测时间为2 s左右,检出限为0.001~0.5 ng/mL,定量限为0.005~2 ng/mL。在3个数量级的质量浓度范围内,28种芬太尼类新精神活性物质均有良好的线性关系,相关系数(R2)均大于0.99,方法回收率在92.6%~106.3%之间,相对标准偏差(RSD)均小于10%。该方法可用于尿液中芬太尼类新精神活性物质的现场快速检测。A method of pulsed direct current electrospray ionization mass spectrometry(pulsed-dc-ESI-MS)was developed to achieve rapid detection of 28 kinds of fentanyl new psychoactive substances in urine.The urine was extracted by ethyl acetate and the supernatant was injected by pulsed-dc-ESI.The results showed that the detection time was only 2 s,the limits of detection were 0.001-0.5 ng/mL and the limits of quantitative were 0.005-2 ng/mL.In addition,in the concentration range of three orders of magnitude,28 fentanyl had good linear relationships,with all the correlation coefficients(R^(2))greater than 0.99.The method possessed recoveries of 92.6%-106.3%,and the relative standard deviations(RSDs)for 28 fentanyl were less than 10%.This method can be used for on-site rapid detection of fentanyl in urine.

关 键 词：芬太尼 新精神活性物质 脉冲直流电喷雾质谱 尿液 现场快速检测 

分 类 号：O657.63[理学—分析化学]