皮肤及软组织感染中金黄色葡萄球菌临床分布和耐药特性分析  

Clinical distribution and drug resistance of Staphylococcus aureus in skin and soft tissue infections

作　　者：董霞[1] Dong Xia(Department of Dermatology and Venereal Diseases,Tianjin Public Security Hospital,Tianjin 300042,China)

机构地区：[1]天津市公安医院,天津300042

出　　处：《首都食品与医药》2023年第18期45-47,共3页Capital Food Medicine

摘　　要：目的探讨皮肤及软组织感染中金黄色葡萄球菌的临床分布特点,分析其耐药特性。方法选择2020年1月-2022年12月天津市公安医院40例皮肤及软组织感染患者为对象,从其中分离金黄色葡萄球菌,总结金黄色葡萄球菌疾病、科室分布情况。采用全自动微生物鉴定系统做菌株鉴定和药敏试验,总结其耐药性。结果40例患者标本分离获得103株菌株,其中45株为金黄色葡萄球菌。疾病分布占比最高的为皮肤脓肿、肿,随后为带状疤疹继发感染、甲沟炎。金黄色葡萄球菌进一步分析,以头孢西丁纸片法明确其中占比,可见耐甲氧西林、甲氧西林敏感的金黄色葡萄球菌占比分别为26.67%(12/45)、73.33%(33/45)。对于青霉素、克林霉素、四环素高度耐药,对万古霉素、替考拉宁、替加环素等抗生素,金黄色葡萄球菌具备高敏感性。结论皮肤及软组织感染中,金黄色葡萄球菌感染以甲氧西林敏感为主,应强化此类患者菌株分离和鉴定,指导抗生素使用,不同菌株的耐药情况有差异,应根据实际结果科学、合理地选择药物,提高对皮肤及软组织的感染控制、治疗效果,保证治疗的有效性和安全性。Objective To investigate the clinical distribution of Staphylococcus aureus in skin and soft tissue infections and analyze their drug resistance.Methods From January 2020 to December 2022,40 patients with skin and soft tissue infection in our hospital were selected.The Staphylococcus aureus were isolated and the distribution of Staphylococcus aureus diseases and departments were summarized.Automatic microbial identification system was used for strain identification and drug sensitivity test to summarize its drug resistance.Results 103 strains were isolated from 40 patients,45 of which were Staphylococcus aureus.The highest disease distribution was skin abscess,furuncle,followed by herpes zoster secondary infection,paronychitis.Further analysis of Staphylococcus aureus showed that the proportion of methicillin-resistant Staphylococcus aureus and methicillin-sensitive Staphylococcus aureus were 26.67%(12/45)and 73.33%(33/45),respectively,by using cefoxitin paper method.Staphylococcus aureus is highly resistant to penicilin,clindamycin and tetracycline,and highly sensitive to vancomycin,tegacycline and tegacycline.Conclusion Staphylococcus aureus infection of skin and soft tissue infection is mainly sensitive to methicillin.It is necessary to strengthen the isolation and identification of these patients,and guide the use of antibiotics.Drug resistance of different strains is different.

关 键 词：皮肤及软组织感染 金黄色葡萄球菌 临床分布 耐药特性分析 

分 类 号：R753[医药卫生—皮肤病学与性病学]