PRP联合外用重组人碱性成纤维细胞生长因子治疗烧伤慢性创面效果观察  

Cosmetic Results of PRP Combined with External Application of Recombinant Human Basic Fibroblast Growth Factor in the Treatment of Chronic Burn Wounds

作　　者：许贤君 刘伟源[1] 陈燕图 陆国健 XU Xianjun;LIU Weiyuan;CHEN Yantu;LU Guojian(Department of Burn Plastic Surgery,Guangxi Wuzhou Red Cross Hospital,Wuzhou 543000,Guangxi,China;Department of Blood Transfusion,Guangxi Wuzhou Red Cross Hospital,Wuzhou 543000,Guangxi,China)

机构地区：[1]广西梧州市红十字会医院烧伤整形外科,广西梧州543000 [2]广西梧州市红十字会医院输血科,广西梧州543000

出　　处：《中国美容医学》2023年第9期36-39,共4页Chinese Journal of Aesthetic Medicine

基　　金：梧州市科学研究与技术开发计划项目(编号:2021F01315)。

摘　　要：目的:探究富血小板血浆(Platelet rich plasma,PRP)联合外用重组人碱性成纤维细胞生长因子治疗烧伤慢性创面效果。方法:回顾性分析梧州市红十字会医院2019年12月-2021年12月收治的120例烧伤慢性创面患者资料,按照治疗方法不同分为观察组(n=64)和对照组(n=56),对照组给予外用重组人碱性成纤维细胞生长因子喷洒创面,观察组采用自制PRP与重组人碱性成纤维细胞生长因子粉剂配置的混合液喷洒或外涂创面,并观察两组患者创面愈合率和愈合时间、瘢痕增生情况、血清炎性因子和并发症情况。结果:观察组患者的创面愈合时间低于对照组(P<0.05),观察组的创面愈合率为96.88%,高于对照组的85.71%(P<0.05)。观察组治疗后1、3、6、12个月的温哥华瘢痕量表(Vancouver scar scale,VSS)评分值低于对照组(P<0.05)。治疗后,两组患者的C-反应蛋白和白细胞计数水平均降低,且观察组低于对照组(P<0.05)。观察组的并发症发生率为3.13%,显著低于对照组的16.07%(P<0.05)。结论:PRP联合外用重组人碱性成纤维细胞生长因子治疗烧伤慢性创面效果良好。Objective The aim of this study was to explore the cosmetic results of platelet-rich plasma(PRP)combined with external application of recombinant human basic fibroblast growth factor in the treatment of chronic burn wounds.Methods Data of 120 patients with chronic burn wounds admitted to Wuzhou Red Cross Hospital from December 2018 to December 2020 were retrospectively analyzed,and divided into observation group(n=64)and control group(n=56)according to different treatment methods.The control group was sprayed with external recombinant human basic fibroblast growth factor,and the observation group was sprayed with a mixture of self-made PRP and recombinant human basic fibroblast growth factor powder.The healing rate and healing time of the wound,scar hyperplasia,serum inflammatory factors and complications of the two groups were observed.Results The wound healing time in the observation group was shorter than that in the control group(P<0.05),and the wound healing rate(96.88%)was higher than that in the control group(85.71%)(P<0.05).The observation group had lower VSS scores than the control group at 1,3,6 and 12 months after treatment(P<0.05).After treatment,C-reactive protein level and white blood cell count were decreased in the two groups,and were lower in the observation group than in the control group(P<0.05).The incidence of complications in the observation group(3.13%)was significantly lower than that in the control group(16.07%)(P<0.05).Conclusion PRP combined with external application of recombinant human basic fibroblast growth factor can achieve good cosmetic results in the treatment of chronic burn wounds.

关 键 词：富血小板血浆 成纤维细胞 生长因子 烧伤 修复 慢性创面 

分 类 号：R644[医药卫生—外科学]