水光注射联合Q开关1064 nm激光治疗黄褐斑  

Melasma Treatment with Intradermal Injection Combined with Q-switched 1064 nm Laser

作　　者：季孙平[1] 赵一栋[1] 许芳 陈银雪 徐文[1] JI Sunping;ZHAO Yidong;XU Fang;CHEN Yinxue;XU Wen(Department of Dermatology,Changshu No.2 People’s Hospital,Changshu 215500,Jiangsu,China;Changshu Fushui Qingyan Medical Beauty Clinic,Changshu 215505,Jiangsu,China)

机构地区：[1]常熟市第二人民医院皮肤科,江苏常熟215500 [2]常熟市拂水晴颜医疗美容诊所,江苏常熟215505

出　　处：《中国美容医学》2023年第9期96-100,共5页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探讨水光注射透明质酸钠、氨甲环酸、谷胱甘肽联合Q开关1064 nm激光对黄褐斑患者疗效及生活质量的影响。方法:选取2018年6月-2019年12月笔者医院收治的黄褐斑女性患者112例,根据患者治疗方案分为研究组55例和对照组57例。对照组采用Q开关1064 nm激光治疗,研究组采用水光注射透明质酸钠、氨甲环酸、谷胱甘肽联合Q开关1064 nm激光治疗,每4周1次,疗程共6个月。比较两组疗效及1年后复发率,比较治疗3、6个月后的黄褐斑生活质量评分量表(Chinesemelasma quality of life scale,Ch-MELASQOL)评分、黄褐斑面积与严重程度指数量表(MASI)评分、满意度评分。结果:治疗6个月后,研究组总有效率为80.00%高于对照组的57.89%。随访1年,研究组无复发,对照组复发率10.53%(6/57)高于研究组(P<0.05)。治疗3、6个月后,研究组的Ch-MELASQOL评分、MASI评分均低于对照组(P<0.05)。研究组治疗后的满意度评分高于对照组(P<0.05)。结论:水光注射透明质酸钠、氨甲环酸、谷胱甘肽联合Q开关1064 nm激光治疗黄褐斑效果良好,可提高患者生活质量,减少复发。Objective To investigate the effects of intradermal injection of sodium hyaluronate,tranexamic acid and glutathione combined with Q-switched 1064 nm laser on efficacy and quality of life of patients with melasma.Methods A total of 112 female patients with melasma were selected from June 2018 to December 2019.According to the treatment plan,they were divided into study group(55 cases)and control group(57 cases).The control group was treated with Q-switched 1064 nm laser,while the study group was treated with intradermal injection of sodium hyaluronate,tranexamic acid and glutathione combined with Q-switched 1064 nm laser,once every 4 weeks.Both groups were given 6 months of treatment.Comparison was made between the two groups in terms of efficacy,recurrence rate within 1 year,the Ch-MELASQOL scores,MASI scores and satisfaction scores after 3 and 6 months of treatment.Results After 6 months of treatment,the total response rate in the study group(80.00%)was higher than that in the control group(57.89%).During 1 year of follow-up,there was no recurrence in the study group,but the recurrence rate in the control group was 10.53%(6/57)(P<0.05).After 3 and 6 months of treatment,the Ch-MELASQOL scores and MASI scores of the study group were lower than those of the control group(P<0.05),and satisfaction score after treatment was higher than that of the control group(P<0.05).Conclusion Intradermal injection of sodium hyaluronate,tranexamic acid and glutathione combined with Q-switched 1064 nm laser is effective in the treatment of melasma,which can significantly improve the patients’conditions and life quality,and reduce recurrence.

关 键 词：黄褐斑 水光注射 Q开关1064 nm激光 黄褐斑生活质量评分量表 

分 类 号：R758.42[医药卫生—皮肤病学与性病学]