脉冲染料激光与海姆泊芬光动力疗法治疗微静脉畸形的疗效对比分析  

Comparative Analysis of Efficacy of Pulsed Dye Laser and Hemporfi n Photodynamic Therapy in the Treatment of Port-wine Stains

作　　者：肖洁银 陈诚 XIAO Jieyin;CHEN Cheng(Department of Dermatology,Wuhan First Hospital,Wuhan 430000,Hubei,China)

机构地区：[1]武汉市第一医院皮肤科,湖北武汉430000

出　　处：《中国美容医学》2023年第9期107-111,共5页Chinese Journal of Aesthetic Medicine

摘　　要：目的:分析595 nm脉冲染料激光(Pulsed dye laser,PDL)与海姆泊芬光动力疗法(Hemoporfin Photodynamic therapy,HMME-PDT)治疗微静脉畸形的疗效差异。方法:回顾性分析2020年1月-2021年2月于笔者医院就诊的206例微静脉畸形患者的临床资料,根据治疗方法分为观察组和对照组,各103例。观察组接受HMME-PDT治疗,对照组接受595 nm PDL治疗。治疗后评估两组治疗有效率,比较两组患者面部不同分区的微静脉畸形治疗效果及治疗期间不良反应发生率。结果:治疗后3个月时,观察组治疗有效率为70.87%,对照组为62.14%,组间比较差异无统计学意义(P>0.05);两组患者的性别、年龄、颈部皮损、紫红型皮损及增厚型皮损的治疗有效率比较差异无统计学意义(P>0.05),但观察组的面部皮损、四肢躯干皮损及粉红型皮损的治疗有效率显著高于对照组(P<0.05);两组面部额鼻区、眶区及上颌区皮损的治疗有效率比较差异无统计学意义(P>0.05),但观察组面部下颌区皮损的治疗有效率显著高于对照组(P<0.05);治疗期间观察组的色素沉着发生率显著高于对照组(P<0.05)。结论:595 nm PDL、HMME-PDT疗法均可有效治疗微静脉畸形,但HMME-PDT疗法在面部下颌区皮损、四肢躯干皮损及粉红型皮损中应用效果更佳,但易引发色素沉着,故临床应根据患者实际情况,灵活选择治疗方式。Objective Analyze the differences in the efficacy of 595 nm pulsed dye laser(PDL)and hemporfin photodynamic therapy(HMME-PDT)in the treatment of port-wine stains.Methods The clinical data of 206 patients with port-wine stains who were treated in the hospital were retrospectively analyzed between January 2020 and February 2021.According to the treatment methods,the patients were divided into the observation group and the control group with 103 cases in each group.The observation group received HMME-PDT treatment,while the control group was given 595 nm PDL treatment.The effective rate of treatment was evaluated in the two groups.The treatment effects of port-wine stains in different areas of the face were compared between the two groups.The incidence rates of adverse reactions during treatment were recorded in the two groups.Results At 3 months after treatment,the effective rate of treatment was 70.87%in the observation group and 62.14%in the control group(P>0.05).There was no statistical difference in the effective rate of treatment between the two groups from the aspects of gender,age,neck lesions,purple-red skin lesions and thickened skin lesions(P>0.05),but the effective rates of treatment of facial skin lesions,limb trunk skin lesions and pink-type skin lesions in the observation group were significant higher than those in the control group(P<0.05).There were no statistical differences in the effective rates of treatment of lesions in facial frontal-nasal area,orbital area and maxillar y area between the two groups(P>0.05),but the effective rate of treatment of facial mandibular area lesions in the observation group was significantly higher than that in the control group(P<0.05).The incidence rate of hyperpigmentation in the observation group during treatment was significantly higher than that in the control group(P<0.05).Conclusion 595 nm PDL and HMME-PDT can effectively treat port-wine stains.The latter one is more effective in facial mandibular area skin lesions,limb trunk skin lesions and pink-type skin l

关 键 词：脉冲染料激光 海姆泊芬光动力 微静脉畸形 临床疗效 不良反应 

分 类 号：R616.4[医药卫生—外科学]