纳米脂肪在皮肤修复中的应用与机制  

Review on the Application and Mechanism of Nanofat in Skin Repair

作　　者：荆雪 闫琪浩 宁小娜 马天源 谢义德(综述)[5] 刘富伟(审校) JING Xue;YAN Qihao;NING Xiaona;Ma Tianyuan;Xie Yide;LIU Fuwei(Military Medical University of Air Force,Xi'an 710032,Shaanxi,China;Outpatient Department,Fuzhou Enxi Medical Cosmetology Hospital,Fuzhou 350000,Fujian,China;Department of Ophthalmology,Tangdu Hospital,Air Force Military Medical University,Xi'an 710032,Shaanxi,China;Department of Maxillofacial Surgery,Stomatology Hospital of Air Force Military Medical University,Xi'an 710032,Shaanxi,China;Department of Plastic Surgery,Union Hospital Affiliated to Fujian Medical University,Fuzhou 350000,Fujian,China)

机构地区：[1]空军军医大学,陕西西安710032 [2]福州恩喜医疗美容医院门诊部,福建福州350000 [3]空军军医大学唐都医院眼科,陕西西安710032 [4]空军军医大学口腔医院颌面外科,陕西西安710032 [5]福建医科大学附属协和医院整形外科,福建福州350000

出　　处：《中国美容医学》2023年第9期191-196,共6页Chinese Journal of Aesthetic Medicine

基　　金：陕西省重点研发计划一般项目(编号:2021SF-171)。

摘　　要：纳米脂肪是将抽取出的颗粒脂肪机械乳化提纯后留下的微小颗粒组织。一方面,机械乳化过程去除了移植后难以存活的含有大油滴的成熟脂肪细胞,可减轻移植后的炎症反应与吸收;另一方面,随着针对纳米脂肪成分及作用机制研究的不断深入,人们发现纳米脂肪中含有大量脂肪来源干细胞、血管内皮细胞、免疫细胞,以及细胞外基质与生长因子等,这些成分具有促进组织再生的可能。尤其是在皮肤修复领域,纳米脂肪不单能起充填作用,还能促进创面愈合,并可抑制修复后瘢痕,改善皮肤质地与色泽,甚至对毛发等皮肤附属器具有促进修复作用。本文就纳米脂肪在皮肤修复中的综合作用及可能机制展开综述。Nanofat is the tiny particle tissue left after mechanical emulsification and purification of the extracted fat particles.On the one hand,the mechanical emulsification process removes the mature adipocytes containing large oil droplets that are difficult to survive after transplantation,which can reduce the inflammatory reaction and absorption after transplantation.On the other hand,with the deepening of research on the composition and mechanism of nanofat,it has been found that nano-fat contains a large number of adipose-derived stem cells(ADSCs),vascular endothelial cells,immune cells,extracellular matrix and growth factors,which may promote tissue regeneration.Especially in the field of skin repair,nanofat can not only play a filling role,but also promote wound healing,inhibit scar after repair,improve skin texture and color,and even promote skin accessories such as hair.This article reviews the comprehensive effect and possible mechanism of Nanofat in skin repair.

关 键 词：纳米脂肪 皮肤修复 年轻化治疗 瘢痕 干细胞 创面 脂肪来源干细胞 生长因子 外泌体 血管形成 

分 类 号：R622.9[医药卫生—整形外科]