血管周围干细胞在组织纤维化和损伤修复中的作用  

The Roles of Perivascular Stem Cells in Tissue Fibrosis and Injury Repair

作　　者：李诗媛 周敏[2] 丁利军[1,3] LI Shiyuan;ZHOU Min;DING Lijun(Center for Reproductive Medicine and Obstetrics and Gynecology,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210008,China;Department of Vascular Surgery,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210008,China;Center for Clinical Stem Cell Research,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210008,China)

机构地区：[1]南京大学医学院附属鼓楼医院生殖与妇产医学中心,南京210008 [2]南京大学医学院附属鼓楼医院血管外科,南京210008 [3]南京大学医学院附属鼓楼医院临床干细胞研究中心,南京210008

出　　处：《中国细胞生物学学报》2023年第8期1248-1256,共9页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81871728)资助的课题。

摘　　要：血管周围干细胞包含微血管中紧邻血管内皮细胞的周细胞,以及定居于大血管最外层的血管外膜细胞,在生理状态下主导血管新生、调节血管稳态。在组织炎症损伤等病理状态下,血管周围干细胞脱离血管周生物“龛”,快速增殖、分化为肌成纤维细胞,是导致组织纤维化、疤痕病变的重要原因之一。同时,血管周围干细胞具有多种典型的间充质干细胞表型,是体内外间充质干细胞的主要来源,向组织损伤区域移植或递送血管周围干细胞,可有效促进组织损伤修复与重建。该综述归纳总结了血管周围干细胞的特性,以及其在生理、病理和疾病治疗中的多重作用,为解析组织器官稳态维持机制以及重塑损伤组织功能提供了新思路。Perivascular cells,including pericytes adjacent to vascular endothelial cells in microvessels,and adventitial cells residing in the outermost layer of large blood vessels,dominate angiogenesis and regulate vascular homeostasis in physiological states.In pathological conditions such as tissue injury and inflammation,perivascular cells leave the perivascular niche,rapidly proliferate and transdifferentiate into myofibroblasts,which are one of the important reasons for the formation of tissue fibrosis and scarring lesions.Besides,perivascular cells present typical mesenchymal stem cell phenotypes,which are the main source of in vivo and ex vivo mesenchymal stem cells,and can effectively promote tissue repair and reconstruction by transplantation or delivery to the injury sites.This review summarizes the characteristics of perivascular stem cells and their multiple roles in physiology,pathology and disease treatments,in order to provide novel insights into deciphering the mechanisms of tissue hemostasis and the functional reconstruction of injured tissue.

关 键 词：血管周围干细胞 间充质干细胞 组织纤维化 组织再生 

分 类 号：R331[医药卫生—人体生理学]