肠道干细胞标记物的研究进展  

Progresses in the Research of Intestinal Stem Cells Markers

作　　者：李梅[1] 童乐 黄玲[1] 唐小涵 张长城[1] 郭煜晖[1] LI Mei;TONG Le;HUANG Ling;TANG Xiaohan;ZHANG Changcheng;GUO Yuhui(Third-Grade Pharmacological Laboratory on Traditional Chinese Medicine,State Administration of Traditional Chinese Medicine,Medical College,China Three Gorges University,Yichang 443002,China)

机构地区：[1]三峡大学国家中医药管理局中药药理科研三级实验室,三峡大学健康医学院,宜昌443002

出　　处：《中国细胞生物学学报》2023年第8期1265-1272,共8页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81873349)资助的课题。

摘　　要：肠道干细胞(intestinal stem cells,ISCs)除了具有自我更新能力和多能性外,还表现出活跃的增殖、信号活动以及特殊的表观遗传和代谢特征。其主要作用是维护肠道组织的稳态、修复受损的肠道黏膜和调节肠道细胞分化。目前,主要有两种ISCs,各自拥有不同的特异性标记物且具有广泛不同的生物学功能,但都与肠道疾病的发生和发展关系密切。然而,ISCs标记物的缺乏严重限制了对ISCs生物学特性的研究,阻碍了临床上ISCs及其衍生物用于治疗肠道相关疾病的研究进程。以下就近年来ISCs标记物及肠道诱导多能干细胞(induced pluripotent stem cells,iPSCs)的研究进展作一综述,旨在为临床治疗肠道疾病提供有益线索。In addition to self-renewal and pluripotency,ISCs(intestinal stem cells)also exhibit active proliferation,signaling activities,and special epigenetic and metabolic characteristics.The main role is to maintain the homeostasis of intestinal tissue,repair damaged intestinal mucosa and regulate intestinal cell differentiation.At present,there are two main types of ISCs,each of which has different specific markers and widely different biological functions,but they are closely related to the occurrence and development of intestinal diseases.Nevertheless,the lack of ISCs markers seriously limits the study of the biological characteristics of ISCs and hinders the clinical application of ISCs and its derivatives in the treatment of gut-related diseases.This article reviews the research progress of ISCs markers and intestinal iPSCs(induced pluripotent stem cells)in recent years,intend to provide useful clues for the clinical treatment of intestinal diseases.

关 键 词：肠道干细胞 LGR5 Olfm4 BMI1 LRIG1 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]