基于“毒损”理论探讨“态靶结合”治疗糖尿病大血管病变  

Treatment of diabetic macroangiopathy based on the state-target differentiation from the perspective of toxin damage theory

作　　者：彭雨婷 刘添娇 朴春丽 PENG Yuting;LIU Tianjiao;PIAO Chunli(Guangzhou University of Chinese Medicine,Guangzhou 510006,China;Shenzhen Hospital,Guangzhou University of Chinese Medicine,Shenzhen 518000,China)

机构地区：[1]广州中医药大学,广州510006 [2]广州中医药大学深圳医院〔福田〕,广东深圳518000

出　　处：《吉林中医药》2023年第9期997-1000,共4页Jilin Journal of Chinese Medicine

基　　金：国家自然科学基金(81973813);广东省中医药局科研项目(20221329)。

摘　　要：糖尿病大血管病变作为糖尿病的重要并发症之一,其病理机制复杂,为糖尿病并发症防治过程中的难点和重点。中医认识本病从“毒损”理论角度切入,正虚邪盛,痰、瘀、湿、浊蕴结不解而成毒,损伤脉管,致使结构和组织功能失常。朴春丽教授根据“态靶结合”辨证组方思想,以正虚毒损为态,痰瘀湿浊、糖脂之毒、动脉粥样硬化为靶,补虚、解毒、通络,开创解毒通络开痹方,态靶同调,取得良好临床疗效。As one of the key complications of diabetes,diabetic macroangiopathy is a disease that seriously endangers the public health in China,as its complex pathological mechanism is the difficult and key point in the prevention and treatment of diabetes complications and there is no good therapeutic effect for it in modern medicine.In traditional Chinese medicine,this disease is recognized from the perspective of the theory of"toxin damage",where,owing to the healthy qi deficiency and pathogen excessiveness,the accumulation of phlegm,blood stasis,dampness and turbidity cannot be resolved and turns into toxins,which can damage the blood vessels and results in a disorder in their structure and tissue.Professor Piao Chunli,under the guidance of delivering a treatment and formulating a prescription based on the"state-target"differentiation,takes the healthy qi deficiency and toxin damage as the states of the disease,and phlegm,blood stasis,dampness,turbidity,the toxins of blood glucose and blood lipid,and atherosclerosis as its targets,treating diabetic macroangiopathy by tonifying deficiency,removing toxins and unblocking the channels.She creates the Jiedu Tongluo Kaibi Formula and achieves a good clinical effect in the treatment of the disease.

关 键 词：糖尿病大血管病变 态靶 毒损 解毒通络开痹方 仝小林 

分 类 号：R255.4[医药卫生—中医内科学]