生精3号方治疗肾虚血瘀型少弱畸精子不育症临床研究  

Clinical Study on Shengjing No.3 Formula(生精3号方)in Treating Oligoasthenozoospermia Infertility of Kidney Deficiency and Blood Stasis Type

作　　者：梁世佳 毛剑敏 韩文均[1] 刘鹏[1] 於全要 王俊博 梁博闻 孙建明[1] LIANG Shijia;MAO Jianmin;HAN Wenjun;LIU Peng;YU Quanyao;WANG Junbo;LIANG Bowen;SUN Jianming(The Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200137,China)

机构地区：[1]上海中医药大学附属第七人民医院,上海200137

出　　处：《山东中医杂志》2023年第10期1062-1066,共5页Shandong Journal of Traditional Chinese Medicine

基　　金：浦东新区国家中医药发展综合改革试验区建设项目,中医专科品牌建设倍增计划-中医男性病专科(编号:PDZY-2021-0307);浦东新区卫生系统重点亚专科建设资助(编号:PWZy2022-02)。

摘　　要：目的:观察生精3号方治疗肾虚血瘀型少弱畸精子不育症的临床疗效。方法:选取肾虚血瘀型少弱畸精子不育症患者120例,按随机数字表法分为观察组和对照组各60例。观察组予生精3号方治疗,对照组予中成药五子衍宗丸治疗。两组均治疗3个月。治疗3个月后,比较两组患者精子密度、前向运动精子百分率(PR)、正常形态精子率、精子DNA碎片指数(DFI)、精浆果糖、α-葡糖苷酶、精浆锌、中医证候积分,评价临床疗效与安全性。结果:治疗后,观察组精子密度、PR、正常形态精子率、中医证候积分、DFI、精浆果糖水平均较治疗前改善(P<0.05),对照组精子密度、PR、正常形态精子率、中医证候积分均较前改善(P<0.05);组间比较,观察组在精子密度、PR、正常形态精子率、中医证候积分、DFI方面的改善优于对照组(P<0.05)。治疗后,观察组痊愈13例,总有效率83.3%,对照组痊愈8例,总有效率68.3%,观察组疗效优于对照组(P<0.05)。两组均未发生不良反应。结论:生精3号方可安全有效地提高肾虚血瘀型少弱畸精子不育症患者的精子密度、PR及正常形态精子率,从而提高配偶妊娠概率。Objective:To observe the clinical effect of Shengjing No.3 Formula(生精3号方)in treating oligoasthenozoospermia infertility of kidney deficiency and blood stasis type.Methods:A total of 120 patients with oligoasthenozoospermia infertility of kidney deficiency and blood stasis type were divided into the observation group and the control group according to random number table method,with 60 cases in each group.The observation group was treated with Shengjing No.3 Formula,and the control group was treated with Wuzi Yanzong Pill(五子衍宗丸).Both groups were treated for 3 months.After 3 months of treatment,the sperm density,percentage of sperm progressive motility rate(PR),normal sperm form rate,sperm DNA fragment index(DFI),semen berry sugar,α-glucosidase,seminal plasma zinc and traditional Chinese medicine(TCM)syndrome score of the two groups were compared to evaluate the clinical efficacy and safety.Results:After treatment,the sperm density,PR,normal form sperm rate,TCM syndrome score,DFI and semen berry sugar level in the observation group were improved compared with those before treatment(P<0.05),while the sperm density,PR,normal form sperm rate and TCM syndrome score in the control group were improved compared with those before treatment(P<0.05).The improvement of sperm density,PR,normal sperm rate,TCM syndrome score and DFI in the observation group were better than those in the control group(P<0.05).After treatment,13 cases were cured in the observation group,the total effective rate was 83.3%,and 8 cases were cured in the control group,the total effective rate was 68.3%.The curative effect of the observation group was better than that of the control group(P<0.05).No adverse reactions occurred in both groups.Conclusion:Shengjing No.3 Formula can safely and effectively improve the sperm density,PR and normal form sperm rate of oligoasthenozoospermia infertility patients of kidney deficiency and blood stasis type,so as to increase the pregnancy ratio of spouses.

关 键 词：生精3号方 五子衍宗丸 少弱畸形精子症 男性不育症 肾虚血瘀 

分 类 号：R256.56[医药卫生—中医内科学]