Wip1在炎症反应中的研究进展  

Research progress of Wip1 in inflammation

作　　者：黄俊锴 漆雨晨 宋颖辉 刘苏来 HUANG Jun-kai;QI Yu-chen;SONG Ying-hui#;LIU Su-lai(Department of Hepatobiliary Surgery,Hunan Research Center of Biliary Disease,Hunan Provincial People's Hospital,Changsha 410005,China;Department of Cardiology,Xiangdong Hospital,Hunan Normal University,Liling 412200,China)

机构地区：[1]湖南省人民医院(湖南师范大学附属第一医院)肝胆外科,湖南省胆道疾病研究中心,长沙410005 [2]湖南师范大学附属湘东医院心血管内科,醴陵412200

出　　处：《现代免疫学》2023年第4期318-323,共6页Current Immunology

基　　金：国家自然科学基金项目(青年基金81902017);湖湘青年英才支持项目(2020RC3066);湖南省优秀博士后创新人才支持项目(2020RC2064);湖南省肝胆胰肠诊疗能力提升项目(湘卫[2019]118号)。

摘　　要：炎症反应是具有血管系统的活体组织对各种损伤因子的刺激所发生的以防御反应为主的病理生理过程。野生型p53诱导的磷酸酶1(wild-type p53-induced phosphatase 1,Wip1)是一种由镁离子/锰离子依赖性蛋白激酶1D(protein phosphatase,Mg^(2+)/Mn^(2+)dependent 1D,PPM1D)编码的丝氨酸/苏氨酸磷酸酶,属PP2C家族。Wip1通过去磷酸化p38 MAPK、p53和共济失调毛细血管扩张突变(ataxia telangiectasia-mutated,ATM)激酶等多种重要的信号分子调控细胞核的DNA损伤修复和炎症细胞的增殖、衰老、凋亡及自噬。越来越多的研究证实,Wip1对许多炎症细胞起着关键性的调节作用,文章就Wip1的结构特点、Wip1与炎症细胞的关系以及在炎症性疾病中的作用等研究进展展开综述。Inflammation is a pathological process dominated by the defensive response to the stimulation of various damage factors in living tissues with the vascular system.Wild-type p53-induced phosphatase 1(Wip1)is a PP2C family serine/threonine phosphatase encoded by protein phosphatase,Mg^(2+)/Mn^(2+)dependent 1D(PPM1D)gene.Wip1 regulates DNA damage repair and the proliferation,senescence,apoptosis,and autophagy of inflammatory cells through regulation of important signaling molecules including dephosphorylation of p38 MAPK,p53 and ataxia telangiectasia-mutated(ATM)protein.Increasing studies have confirmed that Wip1 plays a key role in regulating many types of inflammatory cells.This review summarizes the structural characteristics of Wip1,the relationship between Wip1 and inflammatory cells,and the role of Wip1 in inflammatory diseases.

关 键 词：野生型p53诱导的磷酸酶1 镁离子/锰离子依赖性蛋白激酶1D 炎症反应 

分 类 号：R392.9[医药卫生—免疫学]