甲状腺激素影响巨噬细胞表型和功能的研究进展  

Research progress on the effect of thyroid hormone on macrophage phenotype and function

作　　者：王乙楠 闫东梅[1] WANG Yi-nan;YAN Dong-mei(Department of Immunology,College of Basic Medical Sciences,Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学基础医学院免疫学系,长春130021

出　　处：《现代免疫学》2023年第4期324-328,共5页Current Immunology

基　　金：国家自然科学基金面上项目(81871245);吉林省科学技术厅课题(20210509009RQ)。

摘　　要：甲状腺激素(thyroid hormone,TH)包括三碘甲状腺原氨酸(3,5,3’-triiodothyronine,T3)和四碘甲状腺原氨酸(3,5,3’,5’-tetraiodothyronine,T4,或称为甲状腺素)2种形式,几乎作用于机体的所有组织,生物效应十分广泛,可调节机体的新陈代谢与生长发育,尤其是对固有免疫细胞的影响近年来受到重视。巨噬细胞表达甲状腺素受体,其2种激活状态(M1型和M2型)受甲状腺素的调节。此外,巨噬细胞还表达二型脱碘酶(type 2 deiodinase,D2),可调控细胞内TH的不同分子形式。而甲状腺功能异常也会影响巨噬细胞的生物学活性,如抑制炎症、甲状腺功能减退加重动脉粥样硬化等。尽管目前对于甲状腺激素和巨噬细胞间的临床相关性尚缺乏充足的证据,但可通过推论预测机体感染、肿瘤和自身免疫性疾病等的临床易感性。There are two forms of thyroid hormone(TH):3,5,3'-triiodothyronine(T3)and 3,5,3',5'-tetraiodothyronine(T4,or termed thyroxine).They act on almost all tissues of the body,with a wide range of biological processes including metabolism,growth,and development.Recent studies have brought attention to their regulation on innate immune cells.Thyroxine has been shown to affect the M1 and M2 states of macrophages.In addition,macrophages express type 2 deiodinase(D2),which can regulate different molecular forms of intracellular TH.The abnormal thyroid function also affects the biological activity of macrophages such as their anti-inflammatory activity.In addition,hypothyroidism aggravates atherosclerosis.Although there is no sufficient evidence to prove the clinical correlation between thyroid hormones and macrophages,thyroid hormone level may be used as a factor to predict clinical susceptibility to infections,tumors,and autoimmune diseases.

关 键 词：巨噬细胞 甲状腺激素 三碘甲状腺原氨酸 甲状腺素 小胶质细胞 

分 类 号：R392.6[医药卫生—免疫学]