巨噬细胞在草酸钙肾结石中的作用研究进展  

Research progress on the role of macrophages in calcium oxalate nephrolithiasis

作　　者：杨雄 靳潇潇 何文强 YANG Xiong;JIN Xiao-xiao;HE Wen-qiang(The First Clinical Medical School,Henan University of Chinese Medicine,Zhengzhou 450000,China;Urology Ward 2,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第一临床医学院,郑州450000 [2]河南中医药大学第一附属医院泌尿外科二病区,郑州450000

出　　处：《现代免疫学》2023年第4期346-350,共5页Current Immunology

基　　金：河南省重点研发与推广专项(科技攻关)(182102310059)。

摘　　要：肾结石具有较高的发病率和复发率,目前已成为泌尿外科所面临的难题。近年来研究发现巨噬细胞在草酸钙肾结石的发生、发展中发挥重要作用。巨噬细胞通过极化为不同的亚型,分泌细胞因子,吞噬晶体及介导信号转导通路等多种途径参与草酸钙肾结石的发生、发展。该文就巨噬细胞在草酸钙肾结石中作用机制的研究进展进行综述。Kidney stone is a disease of high incidence and recurrence rate and has become an obstacle in urology.Recent studies have demonstrated the role macrophages play in the development of calcium oxalate nephrolithiasis.Macrophages regulate the occurrence and development of calcium oxalate nephrolithiasis via various mechanisms,such as polarization into different subtypes,secretion of cytokines,crystals phagocytosis,and activation of signal transduction pathways.This review discusses the research progress on the mechanism of macrophages in calcium oxalate nephrolithiasis.

关 键 词：肾结石 草酸钙结石 巨噬细胞 炎症反应 

分 类 号：R692.4[医药卫生—泌尿科学]