Meta分析CD14基因-159C/T多态性与变应性鼻炎易感性关系  

Meta analysis of the relationship between CD14 gene-159C/T polymorphism and susceptibility to allergic rhinitis

作　　者：单立影 徐景利 赵亚娟 田海芳 SHAN Li-ying;XU Jing-li;ZHAO Ya-juan;TIAN Hai-fang(Otolaryngology Department,Beijing Traditional Chinese Medicine Hospital Shunyi Hospital,Beijing 101300,China)

机构地区：[1]北京中医医院顺义医院耳鼻喉科,101300

出　　处：《中国医药生物技术》2023年第5期421-427,共7页Chinese Medicinal Biotechnology

摘　　要：目的Meta分析CD14基因-159C/T多态性与变应性鼻炎(AR)易感性关系,为AR的发病机制及疾病预防提供理论依据。方法检索PubMed、EMBASE、Cochrane等国外数据库及中国期刊全文数据库、中国科技期刊数据库、中国生物医学文献数据库、万方数字期刊全文数据库等中文数据库中发表的CD14基因-159C/T多态性与变应性鼻炎易感性关系的病例对照研究。根据纳入和排除标准对文献进行筛选,用Jadad quantity对纳入的文献进行偏差评估和敏感性分析,用Revman5.3软件对数据进行处理。结果根据纳入和排除标准,共纳入9篇文献,共2319名受试者,其中病例组1195例,对照组1124例。Meta分析结果显示:优势基因模型下(CC vs CT+TT),组合OR值为0.74,95%CI为[0.61,0.90],P=0.002,差异有统计学意义;超显性基因模型下(CT vs CC+TT),联合OR值为1.12,95%CI为[0.95,1.32],P=0.18,差异无统计学意义;隐性基因模型下(TT vs CC+CT),联合OR值为1.14,95%CI为[0.95,1.38],P=0.15;等位基因(C对T),合并OR值为0.95,95%CI为[0.83,1.10],P=0.50,差异无统计学意义。表明与T等位基因相比,在a位点携带C等位基因不会增加AR的易感性。优势基因模型可能增加基因型CD14基因-159C/T的AR易感性,而隐性基因模型和超显性基因模型可能不会增加基因型CD14基因-159C/T的AR易感性。结论CD14基因-159C/T多态性与AR易感性无显著相关性。基因座中的基因型可能增加AR易感性的基因模型是优势基因模型。Objective To analyze the relationship between the 159C/T polymorphism of CD14 gene and the susceptibility to allergic rhinitis by Meta analysis,and to provide theoretical basis for the pathogenesis and disease prevention of allergic rhinitis(AR).Methods We conducted a case control study on the relationship between CD14 gene-159C/T polymorphism and susceptibility to allergic rhinitis published in foreign databases such as PubMed,EMBASE,Cochrane,and Chinese databases such as the Chinese Journal Full-Text Database,the Chinese Scientific and Technological Journal Database,the Chinese Biomedical Literature Database,and the Wanfang Digital Journal Full-Text Database.Appropriate inclusion and exclusion criteria were selected for the literature,literature screening was performed according to the above criteria,deviation evaluation and sensitivity analysis on the included literature table was conducted with Jadad quantity,and the data were processed with Revman5.3 software.Results According to the inclusion and exclusion criteria,a total of 9 articles with 2319 subjects were included,including 1195 in the case group and 1124 in the control group.The results of Meta analysis showed that under the dominant gene model(CC vs CT+TT),the combined OR value was 0.74 and 95%CI was[0.61,0.90]with a statistically significant difference(P=0.002).In the super dominant gene model(CT vs CC+TT),the combined OR value was 1.12 and the 95%CI was[0.95,1.32]with no statistically significant difference(P=0.18).In the recessive gene model(TT vs CC+CT),the combined OR value was 1.14,the 95%CI was[0.95,1.38],and the value of P was 0.15.The combined OR value of alleles(C versus T)was 0.95 with a 95%CI of[0.83,1.10],and the value of P was 0.50.The difference was not statistically significant.This indicated that carrying the C allele at the a locus did not increase the susceptibility to AR as compared to the T allele.Dominant gene models might increase the AR susceptibility of genotype CD14 gene-159C/T,while recessive gene models and superdominant g

关 键 词：CD14基因-159C/T 多态性 变应性鼻炎 META分析 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]