平均血小板体积预测ST段抬高型心肌梗死患者经皮冠状动脉介入术后主要心脏不良事件Meta分析  

Meta-Analysis of Mean Platelet Volume Predicting Major Cardiac Adverse Events after Percutaneous Coronary Intervention in STEMI Patients

作　　者：郝绍文[1] 于园园[1] 马磊 HAO Shaowen;YU Yuanyuan;MA Lei(Emergency Department,the General Hospital of Ningxia Medical University,Yinchuan 750004,China)

机构地区：[1]宁夏医科大学总医院急诊科,银川750004

出　　处：《宁夏医科大学学报》2023年第7期699-705,721,共8页Journal of Ningxia Medical University

摘　　要：目的 评价平均血小板体积(MPV)对ST段抬高型心肌梗死(STEMI)患者经皮冠状动脉介入术后主要心脏不良事件的预测价值。方法 通过系统检索PubMed、Embase、中国知网(CNKI)、维普和万方数据库等,分析符合标准的队列研究,探索MPV对经皮冠状动脉介入术后预测STEMI患者术后不良事件的影响效应。采用Stata 14.0软件进行分析。结果 共10项研究包含9 409例研究对象,符合纳入、排除标准。结果显示,MPV水平较高组与较低组的STEMI患者经皮冠状动脉介入术后主要不良事件发生率比较,8项研究报道全因死亡,合并效应值RR=2.51,95%CI:1.38~4.57,P=0.003(I^(2)=43.8%,P=0.086);4项研究报道MACEs,合并效应RR=2.41,95%CI:1.34~4.32,P=0.003(I^(2)=74.9%,P=0.007);6项研究报道再发非致命性心肌梗死的预测价值,合并效应值RR=2.01,95%CI:1.40~2.88,P<0.05(I^(2)=0%,P=0.954);5项研究报道了非计划性再次血运重建的预测价值,合并效应值RR=1.42,95%CI:0.76~2.68,P=0.274(I^(2)=72.6%,P=0.006);8项研究报道了院外总MACEs的预测价值,合并效应RR=1.63,95%CI:1.11~2.41,P=0.01(I^(2)=81.3%,P<0.05)。结论 与低MPV水平的STEMI患者相比,MPV升高可有效预测STEMI患者PCI术后院内MACEs、院外总MACEs、全因死亡及再发非致命性心肌梗死的发生风险。Objective To evaluate the predictive value of mean platelet volume in relation to major adverse cardiac events after percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction.Methods PubMed,Embase,China Knowledge Network Infrast nuture,VIP database and Wanfang databases were searched systematically to analyze cohort studies that met the criteria so as to explore the effect of mean platelet volume on predicting postoperative adverse events in patients with ST-segment elevation myocardial infarction after percutaneous coronary intervention.Stata 14.0 was used for statistic analysis.Results Ten studies and a total of 9409 subjects were included in this study,which met the inclusion and exclusion criterions.The pooling effect sizes of all-cause mortality was reported in 8 studiesRR=2.51,95%CI:1.38-4.57,P=0.003(I^(2)=43.8%,P=0.086);For MACEs in 4 studies,the pooling effect sizes RR=2.41,95%CI:1.34-4.32,P=0.003(I^(2)=74.9%,P=0.07);The predictive value of recurrent non-fatal my-ocardial infarction was reported in 6 studies,and the pooling effect sizes RR=2.01,95%CI:1.40-2.88,P<0.05(I^(2)=0%,P=0.954);The predictive value of unplanned revascularization was reported in 5 studies,with a pooling effect sizes RR=1.42,95%CI:0.76-2.68,P=0.274(I^(2)=72.6%,P=0.006).A total of 8 studies reported the predictive value of total out-of-hospital MACEs,with pooling effect sizes RR=1.63,95%CI:1.11-2.41,P=0.01(I^(2)=81.3%,P<0.05).Conclusion Compared with STEMI patients with low MPV level,increased MPV can effectively predict the risk of in-hospital MACEs and out-of-hospital total MACEs which including all-cause death and recurrent nonfatal myocardial infarction in STEMI patients after PCI.

关 键 词：ST段抬高型心肌梗死 经皮冠状动脉介入治疗 平均血小板体积 主要心脏不良事件 META分析 

分 类 号：R542.22[医药卫生—心血管疾病]