PCV2b 1B和1C亚型分离株在猪体致病性的比较  

Comparison of the pathogennicityy of PCV2b 1B and 1C subtype isolates in pigs

作　　者：高杏 高清清[1,3,4] 王小波 陈昌海[5] 开妍 郇长超 高崧 CAO Xing;CAO Qingqing;WANG Xiaobo;CHEN Changhai;KAI Yan;HUAN Changchao;GAO Song(College of Veterinary Medicine,Yangzhou University,Yangzhou 225009,China;Animal Husbandry and Veterinary Station of Gaochun District,Nanjing 211300,China;Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses,Yangzhou 225009,China;MOA Key Laboratory of Poultry Bio-preparations Development,Yangzhou 225009,China;Jiangsu Province Animal Diseases Prevention and Control Center,Nanjing 211000,China;Academy of Agricultural Science and Technology Development,Yangzhou University,Yangzhou 225009,China)

机构地区：[1]扬州大学兽医学院,江苏扬州225009 [2]高淳区漆桥街道畜牧兽医站,江苏南京211300 [3]江苏高校动物重要疫病与人兽共患病防控协同创新中心,江苏扬州225009 [4]农业农村部禽用生物制剂创制重点实验室,江苏扬州225009 [5]江苏省动物疫病预防控制中心,江苏南京211000 [6]扬州大学农业科技发展研究院,江苏扬州225009

出　　处：《畜牧与兽医》2023年第7期81-86,共6页Animal Husbandry & Veterinary Medicine

基　　金：江苏省重点研发计划(现代农业)重点项目(BE2020320);江苏现代农业产业技术体系建设专项资金资助(JATS[2019]346);江苏高校优势学科建设工程资助项目;高等学校学科创新引智计划资助(D18007)。

摘　　要：研究旨在了解PCV2b 1B和1C亚型分离株对低母源抗体商品猪致病性的差异。选取8头32日龄低母源抗体商品猪,随机分成3组,对照组2头,每组试验猪3头,分别感染121108株(PCV2 1B)和130405株(PCV2 1C)毒株后,每7 d采集猪血清,21 d后扑杀比较其致病性。结果表明,121108株感染猪的组织病理学损伤比130405株感染猪更严重,淋巴细胞减少更明显;同时121108株感染猪的淋巴结中分布的PCV2抗原更多。结果提示,对低母源抗体商品猪,PCV2b 1B亚型毒株121108的致病性明显高于PCV2b 1C亚型毒株130405。This study was to compare the pathogenic differences between PCV2b 1B and 1C subtype isolates on commercial pigs of low maternal antibody.Eight 32-day-old commercial pigs with low maternal antibodies were obtained and randomly assigned to three groups:the negative controls(n=2);the PCV2b 1B infected group(121108,n=3),the PCV2b 1C infected group(130405,n=3).The experiment lasted for 21 days,and serum samples were collected from the tested pigs at d7,d14 and d21.Then,the pathogenesis of the two isolates were determined and compared.The histopathology results showed that histopathological damage was more severe in the pigs of the 121108 strain challenged group and there were multinucleated giant cells,a large number of eosinophilia and lymphocyte depleted in their lymph nodes.And more PCV2 antigen was detected in the lymph nodes in the pigs of the 121108 strain challenged group.In conclusion,the results in this study indicated that the infection of the PCV2b 1B strain(121108)was stronger than that of the PCV2b 1C strain(130405).

关 键 词：猪圆环病毒2型 断奶仔猪多系统衰竭综合征 病理组织学 

分 类 号：S855.3[农业科学—临床兽医学]