缺血性中风患者脑功能活动局部一致性改变与认知功能障碍的研究  

A study of regional homogeneity altered of brain function and cognitive dysfunction in patients with ischemic stroke

作　　者：丁菊容 李原 华波 奉晨宇 唐智灵 杨呈浩[3] 丁鑫 DING Jurong;LI Yuan;HUA Bo;FENG Chenyu;TANG Zhiling;YANG Chenghao;DING Xin(College of Automation and Information Engineering,Sichuan University of Science&Engineering,Yibin 644000,China;Artificial Intelligence Key Laboratory of Sichuan Province,Sichuan University of Science&Engineering,Yibin 644000,China;Department of Neurosurgery,Zigong Fourth People's Hospital,Zigong 643000,China;Department of Neurology,Chengdu Second People's Hospital,Chengdu 610000,China)

机构地区：[1]四川轻化工大学自动化与信息工程学院,宜宾644000 [2]四川轻化工大学人工智能四川省重点实验室,宜宾644000 [3]自贡市第四人民医院神经外科,自贡643000 [4]成都市第二人民医院神经外科,成都610000

出　　处：《磁共振成像》2023年第9期7-12,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金(编号:81401482);人工智能四川省重点实验室开放基金(编号:2021RYJ08);成都市卫生健康委员会基金(编号:2022151)。

摘　　要：目的探究静息态下缺血性中风(ischemic stroke,IS)患者脑功能活动的局部一致性(regional homogeneity,ReHo)改变,及其与认知功能障碍之间的联系。材料和方法前瞻性纳入20例IS患者和27例年龄、性别相匹配的健康对照者。所有被试均进行静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)扫描和ReHo分析,通过双样本t检验进行组间差异比较。采用Person相关分析法分析IS患者组异常脑区ReHo值与简易精神状态检查量表(Mini-Mental State Examination,MMSE)和蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)评分之间的相关性。结果与健康对照组相比,IS组右侧额中回、中央后回、颞中回和左侧三角部额下回的ReHo值显著降低,双侧辅助运动区、内侧和旁扣带回、左侧顶上回、楔前叶和中央旁小叶的ReHo值显著增强,差异均具有统计学意义(P<0.001,AlphaSim校正)。此外,双侧辅助运动区和左侧顶上回的ReHo值增高与MMSE评分呈现显著的负相关性(r=-0.640,P=0.014;r=-0.541,P=0.046;r=-0.563,P=0.036)。结论IS患者存在广泛的局部脑功能活动自发性改变,可能与患者认知功能障碍的病理生理学机制有关。异常大脑区域的ReHo值可能是IS中重要的生物学标志物。Objective:To explore the changes of regional homogeneity(ReHo)of resting-state brain activity in patients with ischemic stroke(IS)and its relationship with cognitive dysfunction.Materials and Methods:Twenty patients with IS and 27 age-and sex-matched healthy controls were prospectively enrolled.All subjects underwent resting-state functional magnetic resonance imaging(rs-fMRI)scan and ReHo analysis.The group differences were compared by using two-sample t test.Person correlation analysis was used to analyze the correlation between the abnormal ReHo values and the scores of mini-mental state examination(MMSE)and Montreal cognitive assessment(MoCA)scale in IS patient group.Results:Compared with the healthy control group,the IS patient group showed reduced in ReHo values in the right middle frontal gyrus,postcentral gyrus,middle temporal gyrus and the left inferior frontal gyrus,triangular part.The increased in ReHo values were found in the bilateral supplementary motor area,median cingulate and paracingulate gyri,the left superior parietal gyrus,precuneus and paracentral lobule.The group differences were statistically significant(P<0.001,AlphaSim corrected).In addition,the increased ReHo value in the bilateral supplementary motor area and left superior parietal gyrus showed a significant negative correlation with MMSE score(r=-0.640,P=0.014;r=-0.541,P=0.046;r=-0.563,P=0.036).Conclusions:The spontaneous ReHo changes exist in multiple brain regions in patients with IS,which may be related to cognitive dysfunction.ReHo values in abnormal brain regions may be an important biomarker of IS.

关 键 词：缺血性中风 脑功能活动 局部一致性 认知功能障碍 静息态功能磁共振成像 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R743.3[医药卫生—诊断学]