采用磁共振2D-MRCP电影成像无创评估胰腺外分泌功能的可行性研究  

Noninvasively evaluate pancreatic exocrine function using 2D cine-dynamic MRCP under physiological conditions:A preliminary study

作　　者：吴巧玲 王沄[1] 孙照勇[1] 胡格丽 王一鸣 金征宇[1] 薛华丹[1] WU Qiaoling;WANG Yun;SUN Zhaoyong;HU Geli;WANG Yiming;JIN Zhengyu;XUE Huadan(Department of Radiology,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100730,China;Philips(China)Investment Company Beijing Branch,Bejing 100600,China)

机构地区：[1]中国医学科学院北京协和医院放射科,北京100730 [2]飞利浦(中国)投资有限公司北京分公司,北京100600

出　　处：《磁共振成像》2023年第9期81-85,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：中央高水平医院临床科研专项(编号:2022-PUMCH-B-069)。

摘　　要：目的探讨采用二维磁共振胰胆管成像(two-dimensional magnetic resonance cholangiopancreatography,2D-MRCP)动态电影成像序列定量检测健康志愿者摄入脂餐后主胰管内生理胰液分泌变化的可行性。材料与方法招募健康志愿者36人,所有志愿者均行2D-MRCP电影序列扫描,每个电影序列选择胰头层面,在胰头位置施加宽度为20 mm的空间选择反转脉冲(inversion pulse,IR)饱和带,单层屏气扫描,屏气时长为5 s,屏气间隔为15 s,脂餐前屏气20次采集并测量该志愿者胰液分泌的频率和长度(基础状态的频率和长度),脂餐后屏气60次,观察脂餐后胰液分泌的动态变化。采用配对t检验比较脂餐前后胰液分泌长度的变化,并比较脂餐后胰液分泌频率较基础频率增加百分比。根据年龄将志愿者分为三组,第一组年龄≤30岁,第二组年龄>30岁并≤60岁,第三组年龄>60岁,采用Kruskal-Wallis法比较脂餐后胰液分泌平均频率、平均长度与年龄之间的关系。结果脂餐前胰液分泌的频率为21.32%±1.20%,脂餐后胰液分泌的频率为29.82%±1.11%,频率增加了8.50%,差异具有统计学意义(P<0.001);脂餐前胰液分泌的长度为(11.06±7.27)mm,脂餐后胰液分泌的长度为(15.34±4.61)mm,长度平均增加了4.28 mm,差异具有统计学意义(P<0.05)。第一组与第二、三组之间胰液平均频率和长度差异均具有统计学意义(P<0.001);第二组与第三组之间胰液平均频率和长度差异均无统计学意义(P=0.477,P=0.316)。结论2D-MRCP动态电影序列可定量检测脂餐后胰液分泌流量变化,该序列对无创评估生理状态下胰腺外分泌功能具有临床价值。脂餐后胰液分泌功能随着年龄的增长可能呈下降趋势。Objective:To explore the feasibility of using two-dimensional magnetic resonance cholangiopancreatography(2D-MRCP)dynamic cine imaging sequence to quantitatively detect changes in physiological pancreatic juice secretion in the main pancreatic duct of healthy volunteers after consuming a fat meal.Materials and Methods:Thirty-six healthy volunteers were recruited,all of whom underwent 2D-MRCP film sequence scanning.Each movie sequence selects the pancreatic head layer and applies a 20 mm wide spatial selection inversion pulse(IR)saturation band at the pancreatic head position.Single layer breath-holding scan,with a breath-holding duration of 5 s and a breath-holding interval of 15 s.Collect and measure the frequency and length of pancreatic juice secretion(basic state frequency and length)of the volunteer 20 times before the fat meal,and hold the breath 60 times after the fat meal to observe the dynamic changes in pancreatic juice secretion after the fat meal.Compare the changes in pancreatic secretion length before and after a fat meal using paired t-tests,and compare the percentage increase in pancreatic secretion frequency after a fat meal compared to the base frequency.Volunteers were divided into three groups based on age.The first group was≤30 years old,the second group was>30 years old and≤60 years old,and the third group was>60 years old.The Kruskal Wallis method was used to compare the average frequency of pancreatic juice secretion after a fat meal,and the relationship between the average length and age.Results:The frequency of pancreatic juice secretion before fat meal was 21.32%±1.20%,and the frequency of pancreatic juice secretion after fat meal was 29.82%±1.11%,an increase of 8.50%,with a statistical difference of P<0.001.The length of pancreatic juice secretion before the fat meal was(11.06±7.27)mm,and the length of pancreatic juice secretion after the fat meal was(15.34±4.61)mm,with an average increase of 4.28 mm,showing a statistical difference of P=0.004.According to age group,there were

关 键 词：胰腺 胰腺外分泌功能 胰液频率 胰液长度 脂肪餐 电影序列 磁共振胰胆管成像 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R576[医药卫生—诊断学]