Immunoglobulin A vasculitis nephritis:Current understanding of pathogenesis and treatment  

作　　者：Michela Amatruda Nicolina Stefania Carucci Roberto Chimenz Giovanni Conti 

机构地区：[1]Pediatric Nephrology and Rheumatology Unit,AOU G Martino,University of Messina,Messina 98125,Italy

出　　处：《World Journal of Nephrology》2023年第4期82-92,共11页世界肾病学杂志（英文版）

摘　　要：The clinical spectrum of immunoglobulin A vasculitis nephritis(IgAVN)ranges from the relatively common transitory microscopic hematuria and/or low-grade proteinuria to nephritic or nephrotic syndrome,rapidly progressive glomerulonephritis,or even renal failure.Clinical and experimental studies have shown a multifactor pathogenesis:Infection triggers,impaired glycosylation of IgA1,complement activation,Toll-like-receptor activation and B cell proliferation.This knowledge can identify IgAVN patients at a greater risk for adverse outcome and increase the evidence for treatment recommendations.

关 键 词：Immunoglobulin A vasculitis nephritis Immunoglobulin A vasculitis Henoch-Schoenlein purpura Immunoglobulin A nephropathy Vasculitis glomerulonephritis 

分 类 号：R69[医药卫生—泌尿科学]